{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:08:31Z","timestamp":1759010911457},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":12117,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1973,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The results of Epstein\u2010Barr virus (EBV) neutralization tests on 650 sera from patients with EBV\u2010associated diseases and controls were compared with the titers of antibodies to EB viral capsid antigens (anti\u2010VCA) and to EBV\u2010induced early antigens (anti\u2010EA). All anti\u2010VCA negative sera failed to neutralize EBV. Among 546 anti\u2010VCA positive sera, only eight yielded negative results in neutralization tests. Four of these came from patients in the early acute phase of infectious mononucleosis who subsequently developed neutralizing antibodies. The ratios between neutralizing and anti\u2010VCA titers varied over a wide range indicating that different antibodies are involved in the two tests. In line with the regular presence of mostly elevated anti\u2010VCA titers, the geometric mean neutralizing titers in Burkitt's lymphoma and nasopharyngeal carcinoma were also higher (5\u2010 to 7\u2010fold) than in appropriate controls. In Hodgkin's disease, an over\u2010representation of high neutralizing as well as anti\u2010VCA titers was noted, although some patients had neither of these antibodies. All patients with infectious mononucleosis developed neutralizing antibodies with a geometric mean ultimately matching that of controls whereas in the early acute phase it was lower than in the controls. In contrast, the geometric mean anti\u2010VCA titer in the early acute phase was higher than in controls and then declined in convalescence toward the control value. There was no evident relationship between neutralizing and anti\u2010EA activities whether directed against the D or the R component of the EA complex.<\/jats:p>","DOI":"10.1002\/ijc.2910110315","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T14:19:09Z","timestamp":1171894749000},"page":"637-647","source":"Crossref","is-referenced-by-count":27,"title":["Specific neutralizing antibodies in Epstein\u2010Barr virus associated diseases"],"prefix":"10.1002","volume":"11","author":[{"given":"G.","family":"Rocchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hewetson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Henle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1128\/jb.91.3.1257-1262.1966","article-title":"Complement fixation tests with cell lines derived from Burkitt's lymphoma and acute leukemias","volume":"91","author":"Armstrong D.","year":"1966","journal-title":"J. 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