{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:39:34Z","timestamp":1791221974530,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":11538,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1974,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transformation to continuous cell lines has been studied in cultures of peripheral leukocytes from infectious mononucleosis (IM) patients and in co\u2010cultures of IM leukocytes and foetal cord blood leukocytes of opposite sex. The transformed cells in the co\u2010cultures were of mixed origin with foetal cells usually predominating. Neutralizing antisera to EB virus markedly reduced or abolished the incidence of transformation in IM leukocyte cultures. This effect was not due to cytotoxicity and followed the pattern seen with cultures where transformation was known to depend on the intercellular transfer of infectious EB virus. The findings suggest that EB virus is harboured in peripheral lymphocytes of IM patients as a non\u2010productive unexpressed infection which is activated to produce virus in vitro, the particles released then infecting neighbouring cells to give transformed lines. The differences between this mechanism and the one whereby lines arise in culture from the malignant cells of Burkitt's lymphoma are considered, and their significance is discussed.<\/jats:p>","DOI":"10.1002\/ijc.2910140603","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T15:10:09Z","timestamp":1171897809000},"page":"704-715","source":"Crossref","is-referenced-by-count":71,"title":["Observations on the type of infection by epstein\u2010barr virus in peripheral lymphoid cells of patients with infectious mononucleosis"],"prefix":"10.1002","volume":"14","author":[{"given":"A. B.","family":"Rickinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. H.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)90925-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5668.444"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4058.306"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio233124a0"},{"key":"e_1_2_1_6_1","first-page":"13","article-title":"Control mechanisms in infectious mononucleosis","volume":"18","author":"Denman A. M.","year":"1974","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1128\/jvi.2.7.663-669.1968","article-title":"Demonstration of a herpes group virus in cultures of peripheral leukocytes from patients with infectious mononucleosis","volume":"2","author":"Diehl V.","year":"1968","journal-title":"J. Virol."},{"key":"e_1_2_1_8_1","first-page":"148","volume-title":"Burkitt's lymphoma","author":"Epstein M. A.","year":"1970"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.27.100173.002213"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90874-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196811212792101"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)91517-5"},{"key":"e_1_2_1_13_1","first-page":"855","article-title":"Studies on leukocytes growing in continuous culture derived from normal human donors","volume":"40","author":"Gerber P.","year":"1968","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)91532-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.63.3.740"},{"key":"e_1_2_1_16_1","first-page":"31","article-title":"Induction of infectious mononucleosis in man by the herpes\u2010type virus (HTV) in Burkitt lymphoma cells in tissue culture","volume":"10","author":"Grace J. T.","year":"1969","journal-title":"Proc. Amer. Ass. Cancer Res."},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"Greaves M. F. Brown G. andRickinson A. B. Epstein\u2010Barr virus binding sites on lymphocyte subpopulations and the origin of lymphoblasts in cultured lymphoid cell lines and in the blood of patients with infectious mononucleosis.Clin. Immunol. Immunopath. in press (1974).","DOI":"10.1016\/0090-1229(75)90076-8"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910040311"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.7.1407"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3792.1064"},{"key":"e_1_2_1_21_1","first-page":"1419","article-title":"Evidence for an oncogenic potential of the Epstein\u2010Barr virus","volume":"33","author":"Henle W.","year":"1973","journal-title":"Cancer Res."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.59.1.94"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90182-X"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576505800106"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910140604"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.6.1365"},{"key":"e_1_2_1_27_1","volume-title":"The herpes viruses","author":"Klein G.","year":"1973"},{"key":"e_1_2_1_28_1","first-page":"31","article-title":"Tumor immunolgy","volume":"5","author":"Klein G.","year":"1973","journal-title":"Transplant. Proc."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/222997a0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.3.706"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/237033a0"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-132-34189"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-137-35810"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1001\/jama.1967.03120080053007","article-title":"Culture of normal human leukocytes","volume":"199","author":"Moore G. E.","year":"1967","journal-title":"J. Amer. med. Ass."},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196901)23:1<64::AID-CNCR2820230107>3.0.CO;2-M"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197002122820704"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/jama.1968.03140030037009","article-title":"Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodies","volume":"203","author":"Niederman J. C.","year":"1968","journal-title":"J. Amer. med. Ass."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910080311"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910080312"},{"key":"e_1_2_1_40_1","volume-title":"Viruses, evolution and cancer","author":"Pagano J. S.","year":"1974"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5682.526"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910030619"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910040302"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910010112"},{"key":"e_1_2_1_45_1","first-page":"99","article-title":"The mouse mutant nude does not develop spontaneous tumours\u2014an argument against immunological surveillance","volume":"82","author":"Rygaard J.","year":"1974","journal-title":"Acta path. microbiol. scand. B"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01241456"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91148-3"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.3999.843"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio235216a0"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/34.2.319"},{"key":"e_1_2_1_51_1","first-page":"643","article-title":"Infectious mononucleosis and its relationship to EB vims antibody","author":"University Health Physicians and Phls Laboratories","year":"1971","journal-title":"Brit. med. J."},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-133-34598"},{"key":"e_1_2_1_53_1","first-page":"233","volume-title":"International review of experimental pathology","author":"Zur Hausen H.","year":"1972"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910140603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910140603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T05:08:45Z","timestamp":1699765725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910140603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,12,15]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1974,12,15]]}},"alternative-id":["10.1002\/ijc.2910140603"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910140603","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,12,15]]}}}