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Leukocytes from 73% of patients were cytotoxic for lung\u2010tumour derived cells compared with age\u2010 and sex\u2010matched normal donors, while the frequencies of reactivity against normal adult lung\u2010derived cells and cells from unrelated tumours (e.g. bladder, colon, breast) were 42% and 18% respectively. Leukocytes from lung cancer patients were also cytotoxic for cells derived from foetal lung but susceptibility to cytolysis was variable, cells from 13\u2010 and 14\u2010week embryos revealing greatest reactivity (88%). Leukocytes from patients with a variety of tumours of non\u2010pulmonary origin or with non\u2010malignant conditions (including respiratory disorders) were also reactive with lung\u2010tumour\u2010derived target cells but with a lower overall frequency (35%) than those from lung\u2010cancer patients. The significance of these cytotoxicity data for the existence of tumour\u2010specific host immunoreactivity in lung neoplasia is discussed.<\/jats:p>","DOI":"10.1002\/ijc.2910150216","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T15:57:57Z","timestamp":1171900677000},"page":"308-320","source":"Crossref","is-referenced-by-count":12,"title":["Cell\u2010mediated cytotoxicity to human pulmonary neoplasms"],"prefix":"10.1002","volume":"15","author":[{"given":"B. M.","family":"Vose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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