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In our method anti\u2010human \u03b3\u2010globulin (AHG) was bound to the EBNA antibodies before the complement was added. If only non\u2010complement\u2010fixing antibodies are present the complement can be fixed to the AHG. Within only a few weeks of the onset of infectious mononucleosis (IM) the non\u2010complement\u2010fixing EBNA antibodies reach high titers while the complement\u2010fixing antibodies (detected by the ACIF test) are not yet present. Anti\u2010EBNA\u2010IgM antibodies were not found in the IgM fractions of sera taken at different stages of IM.<\/jats:p>","DOI":"10.1002\/ijc.2910160617","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:08:03Z","timestamp":1171901283000},"page":"1030-1034","source":"Crossref","is-referenced-by-count":7,"title":["Sensitive method to detect non\u2010complement\u2010fixing antibodies to Epstein\u2010Barr virus nuclear antigen"],"prefix":"10.1002","volume":"16","author":[{"given":"H.","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kampa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Heidenreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"13","article-title":"Detection of Epstein\u2010Barr virus (EBV) associated nuclear antigen in human lymphoblastoid cell lines by means of a 126I\u2010IgG binding assay","volume":"1","author":"Brown T. 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