{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:36:13Z","timestamp":1791329773378,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":11141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1976,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stimulated by a report on elevated IgA levels in nasopharyngeal carcinoma (NPC), we tested a total of 372 sera from patients with NPC, other carcinomas of head and neck or elsewhere, Burkitt's lymphoma (BL), infectious mononucleosis (IM) or healthy controls. The sera were titrated in indirect immunofluorescence tests for IgA antibodies to Epstein\u2010Barr virus (EBV) capsid antigen (VCA) and to the diffuse (D) or restricted (R) components of the EBV\u2010induced early antigen (EA) complex. The results proved NPC to be outstanding in that prior to therapy 93% of the patients tested revealed IgA antibodies to VCA and 73% to D, often at high titers which occasionally matched the corresponding IgG antibody levels. The EBV\u2010specific IgA titers increased from stages I or II to stages III or IV; i.e. with the total tumor burden. Conversely, many of the NPC patients examined 2\u20136 years after initial therapy had only low levels of EBV\u2010specific IgA or none at all, and the majority of those with high titers were known to have residual or recurrent disease. In contrast to untreated NPC patients, less than 5% of 73 patients with other carcinomas or of 76 healthy donors revealed VCA\u2010specific IgA and even fewer EA\u2010specific IgA; only 28% and 4% of 54 BL patients tested at admission had IgA antibodies to VCA and R, respectively, and 38% and 3% of 37 IM patients showed transient VCA\u2010or D\u2010specific IgA responses, all at generally low titers. While sera from untreated NPC patients often contained IgA antibodies also to herpes simplex type 1 virus, their incidence and range of low titers were similar to those obtained with sera from patients with other carcinomas or from healthy donors. It thus appears that the elevated IgA levels in NPC might be due to EBV\u2010specific antibodies. Possible reasons for this unique response in NPC have been discussed.<\/jats:p>","DOI":"10.1002\/ijc.2910170102","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:04:41Z","timestamp":1171901081000},"page":"1-7","source":"Crossref","is-referenced-by-count":511,"title":["Epstein\u2010barr virus\u2010specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"17","author":[{"given":"Gertrude","family":"Henle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Henle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"443","article-title":"Epstein\u2010Barr virus\u2010associated antibody patterns in carcinoma of the post\u2010nasal space","volume":"5","author":"de Schryver A.","year":"1969","journal-title":"Clin. exp. 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