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Cross\u2010neutralization tests between EBV strains derived from BL and IM patients and their sera failed to detect differences in the major neutralizing antigenic components. Cord\u2010blood lymphocytes transformed by American EBV expressed only early viral functions (EBV nuclear and soluble complement\u2010fixing antigens) and produced no detectable transforming activity. By contrast, cord\u2010blood lymphocytes transformed by African EBV strains contained 0.2\u20100.3% of cells with EBV capsid and early antigen and produced EBV with transforming activity. These cells contained twice as many copies of EBV homologous DNA as the cells tranformed by American EBV strains.<\/jats:p>","DOI":"10.1002\/ijc.2910170111","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:04:41Z","timestamp":1171901081000},"page":"71-81","source":"Crossref","is-referenced-by-count":51,"title":["Comparative studies of Epstein\u2010barr virus strains from Ghana and the United States"],"prefix":"10.1002","volume":"17","author":[{"given":"Paul","family":"Gerber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis K.","family":"Nkrumah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall","family":"Pritchett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliott","family":"Kieff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"87","volume-title":"Methods in enzymology","author":"Ashwell G.","year":"1957"},{"key":"e_1_2_1_3_1","first-page":"99","volume-title":"Methods in enzymology","author":"Ashwell G.","year":"1957"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/194232a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197312202892501"},{"key":"e_1_2_1_6_1","first-page":"713","article-title":"Characterization of lactic dehydrogenase of normal human granulocytes","volume":"61","author":"Dioguardi N.","year":"1963","journal-title":"J. lab. clin. 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