{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:38:09Z","timestamp":1759207089645},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":11689,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1976,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Of 109 patients with histologically confirmed Burkitt's lymphoma who completed a course of chemotherapy, 86 (79%) achieved complete remission. Forty\u2010five (52%) of patients with initial complete remission relapsed with tumour over an observation period ranging from 2 years to over 5 years. Relapse was more common in patients who initially presented with abdominal or central nervous system (CNS) involvement than in patients who presented with localized facial tumours (p&lt;0.01). Anatomical distribution of tumour on relapse differed from that at presentation. Facial bones were much less frequently involved on relapse; on the other hand, the CNS, cranial nerves, orbits and skin were frequent sites of disease on relapse. CNS involvement occurred in 42% (19\/45) of patients at the first relapse and in 73% (11\/15) of patients with multiple relapses. Prognosis in these patients was poor. Two relapse types were clinically identifiable. Early relapse (remission duration&lt;12 weeks) was associated with frequent involvement of the CNS, drug resistance and a generally unfavourable outcome. Patients with late relapse (remission duration &gt;12 weeks) responded much better to secondary treatment. Possible pathogenic mechanisms underlying these two relapse types are discussed.<\/jats:p>","DOI":"10.1002\/ijc.2910170407","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:01:41Z","timestamp":1171900901000},"page":"455-460","source":"Crossref","is-referenced-by-count":27,"title":["Relapse in Burkitt's lymphoma"],"prefix":"10.1002","volume":"17","author":[{"given":"F. K.","family":"Nkrumah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. V.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92086-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:5<756::AID-CNCR2820200530>3.0.CO;2-P"},{"key":"e_1_2_1_4_1","first-page":"2578","article-title":"Long\u2010term survival of patients with Burkitt's lymphoma","volume":"27","author":"Clifford P.","year":"1967","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5626.288"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197004022821404"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)93019-X"},{"key":"e_1_2_1_8_1","first-page":"251","volume-title":"Cancer in Africa","author":"Frank G. 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Burkitt's lymphoma: a clinical study in 110 patients.Cancer in press (1976).","DOI":"10.1002\/1097-0142(197602)37:2<671::AID-CNCR2820370210>3.0.CO;2-D"},{"key":"e_1_2_1_15_1","first-page":"111","article-title":"Primary neuro\u2010opthalmological presentation of Burkitt's lymphoma","volume":"4","author":"Osuntokun B. O.","year":"1973","journal-title":"Afr. J. med. Sci."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197212)30:6<1534::AID-CNCR2820300619>3.0.CO;2-6"},{"key":"e_1_2_1_17_1","first-page":"1267","article-title":"Relapse patterns in Burkitt's lymphoma","volume":"32","author":"Ziegler J. L.","year":"1972","journal-title":"Cancer Res."},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1182\/blood.V36.6.718.718","article-title":"Central nervous system involvement in Burkitt's lymphoma","volume":"36","author":"Ziegler J. 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