{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:31:45Z","timestamp":1762075905961},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T00:00:00Z","timestamp":1153440000000},"content-version":"vor","delay-in-days":10901,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1976,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hormone responsiveness of pregnancy\u2010independent mammary tumors in SHN mice and pregnancy\u2010dependent tumors in GR\/A mice and in F<jats:sub>1<\/jats:sub>\u2010hybrids between these strains was studied. Force\u2010bred female mice with palpable mammary tumors were given subcutaneous injections of several hormones singly or in combination twice daily from 1 day before to 1 day after parturition. One group received a graft of three pituitary glands under the kidney capsule (3AP) during days 12\u201314 of pregnancy. One day after parturition, the <jats:italic>in vitro<\/jats:italic> incorporation of <jats:sup>3<\/jats:sup>H\u2010thymidine into DNA of normal and neoplastic mammary glands was determined as the index of DNA synthesis. Plasma prolactin in some groups of GR\/A mice was assayed by radioimmunoassay. In GR\/A mice, estradiol benzoate (EB: 0.5 \u03bcg \u00d7 2\/day) or 3AP had no effect on either normal glands or tumors, despite an increase in plasma prolactin level. Progesterone (P: 100 or 1,000 \u03bcg \u00d7 2\/day) significantly increased DNA synthesis of both normal and neoplastic glands when compared to the controls, while the plasma prolactin level in this group was low. The administration of human placental lactogen (HPL: 100 \u03bcg \u00d7 2\/day) stimulated DNA synthesis of normal glands only. P plus HPL promoted DNA synthesis of tumors more than P alone, but not P plus EB. While DNA synthesis of the tumors of SHN was never affected by these hormone treatments, the hormone responsiveness of tumors of F<jats:sub>1<\/jats:sub>\u2010hybrids was almost the same as that of GR\/A mice; the effect of P was prominent. Correlation of DNA synthesis between pregnancy\u2010dependent mammary tumors and normal glands was significant only in groups treated with P alone or in combination with other hormones.<\/jats:p>","DOI":"10.1002\/ijc.2910180308","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:10:45Z","timestamp":1171901445000},"page":"317-321","source":"Crossref","is-referenced-by-count":14,"title":["Importance of progesterone in DNA synthesis of pregnancy\u2010dependent mammary tumors in mice"],"prefix":"10.1002","volume":"18","author":[{"given":"Reiko","family":"Yanai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,21]]},"reference":[{"key":"e_1_2_1_1_1","unstructured":"Boot L. M. Induction of prolactin of mammary tumours in mice. Thesis. Noord\u2010Hollandse Uitgevers Maatschappij N.V. Amsterdam (1969)."},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(73)90069-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(75)90153-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(74)90143-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0620101"},{"key":"e_1_2_1_6_1","first-page":"1217","article-title":"Relation of prolactin and estrogen to mammary tumorigenesis in the rat","volume":"48","author":"Meites J.","year":"1972","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(65)90003-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/jnci\/52.4.1219","article-title":"Effects of estrogen and\/or pituitary grafts on nucleic acid synthesis of carcinogen\u2010induced mammary tumors in rats","volume":"52","author":"Nagasawa H.","year":"1974","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","unstructured":"Nagasawa H. Yanai R. Taniguchi H. Tokuzen R. andNakahara W. Two\u2010way selection of Swiss albino mice for mammary tumorigenesis: establishment of two new strains (SHN and SLN).J. nat. Cancer Inst. in press (1976).","DOI":"10.1093\/jnci\/57.2.425"},{"key":"e_1_2_1_10_1","unstructured":"R\u00f6pcke G. Interaction of hypophyseal isografts and ovarian hormones in mammary tumour development in mice. Thesis. Mondeel\u2010Offsetdrukkerij Amsterdam (1975)."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-91-4-1045"},{"key":"e_1_2_1_12_1","first-page":"3253","article-title":"Estrogen receptor content and hormone responsive growth of mouse mammary tumors","volume":"34","author":"Sluyser M.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(72)90083-7"},{"key":"e_1_2_1_14_1","first-page":"123","article-title":"The role of prolactin in the growth of hormone\u2010dependent GR mouse mammary tumours","volume":"199","author":"Thorpe S. M.","year":"1975","journal-title":"Acta Endocr., Suppl."},{"key":"e_1_2_1_15_1","first-page":"885","article-title":"Biological and morphological characteristics of mammary tumours in GR mice","volume":"46","author":"van Nie R.","year":"1971","journal-title":"J. nat. 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