{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:08:21Z","timestamp":1791151701539,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":10867,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1976,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numbers of B, T and total lymphocytes, monocytes, heterophils, eosinophils and basophils have been examined in the peripheral blood of chickens between 2 and 42 days after infection with Marek's disease virus. During the stage of the acute restrictively productive virus infection of lymphoid tissues at 2\u20139 days after infection, absolute numbers of B cells, T cells, total lymphocytes and heterophils were increased, those of monocytes and eosinophils were decreased, and those of basophils were unchanged. The lymphoproliferative phase of the disease, from 21\u201342 days after infection leading to lymphoma formation, was accompanied by an increase in T cells, total lymphocytes and possibly eosinophils, and a decrease in B cells, monocytes, heterophils and basophils. The T\u2010cell increase following infection occurred only in female birds, and there were more lymphomas in females than in males. The increase in lymphocytes in the blood of six birds with leukemia was mainly due to an increase in T cells, but in one bird B cells were also increased. Blast cells and atypical lymphoid cells were increased in leukemic birds. Regression coefficients were calculated between different pairs of leukocytes in infected and uninfected birds at different stages of the disease. Particularly noteworthy were the associations between B and T cell numbers, which indicated constant proportions of these cells irrespective of total numbers, possibly due to a common control mechanism.<\/jats:p>","DOI":"10.1002\/ijc.2910180416","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:34:57Z","timestamp":1171902897000},"page":"510-520","source":"Crossref","is-referenced-by-count":17,"title":["Sequential changes in the numbers of B and T lymphocytes and other leukocytes in the blood in Marek's disease"],"prefix":"10.1002","volume":"18","author":[{"given":"L. N.","family":"Payne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rennie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/50.5.1287"},{"key":"e_1_2_1_2_1","first-page":"557","volume-title":"The herpesviruses","author":"Biggs P. M.","year":"1973"},{"key":"e_1_2_1_3_1","first-page":"211","article-title":"The etiology of Marek's disease\u2014an oncogenic herpes\u2010type virus","volume":"6","author":"Biggs P. M.","year":"1968","journal-title":"Perspect. Virol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.6.2.193-198.1972"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)93014-7"},{"key":"e_1_2_1_6_1","first-page":"939","article-title":"Herpes\u2010type virus isolated in cell culture from tumors of chickens with Marek's disease. I. Studies in cell culture","volume":"41","author":"Churchill A. E.","year":"1968","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1128\/iai.4.5.567-574.1971","article-title":"Correlation of immunological responsiveness with lymphocyte changes in chickens infected with Marek's disease","volume":"4","author":"Evans D. L.","year":"1971","journal-title":"Infect. Immun."},{"key":"e_1_2_1_8_1","first-page":"47","volume-title":"Infectious mononucleosis","author":"Finch S. 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N.","year":"1976","journal-title":"Int. Rev. exp. Path."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1974.039.01.095"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/51.5.1559"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079457608418179"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/251079a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0034-5288(18)34602-2","article-title":"Characterization of five isolates of Marek's disease","volume":"8","author":"Purchase H. G.","year":"1976","journal-title":"Res. vet. Sci."},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4049\/jimmunol.110.2.534","article-title":"Proportion of T and B lymphocytes in lesions of Marek's disease: theoretical implications for pathogenesis","volume":"110","author":"Rouse B. T.","year":"1973","journal-title":"J. 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