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The incidence of liver tumors was 45% in the DDT\u2010treated group and 44% in the phenobarbital\u2010sodium\u2010group. When evaluated by sex, DDT\u2010treated females and males had incidences of 56% and 35%, respectively, while in the phenobarbital\u2010sodium group, the respective incidences were 32% and 59% in females and males. These data show a varying susceptibility between the sexes, with regard to induction of liver\u2010cell tumors by the two compounds. In both treated groups, the number of nodular tumors per rat and the average size increased with age and were greater in females. None of these tumors had metastasized. Histologically, the liver tumors were nodular growths, which compressed surrounding parenchyma but did not infiltrate it. The total incidence of extrahepatic tumors was higher in controls than in treated animals. In this connection, we must mention the apparent, but not significant, reduction of adrenal tumors in treated rats compared to the controls.<\/jats:p>","DOI":"10.1002\/ijc.2910190207","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:25:47Z","timestamp":1171902347000},"page":"179-185","source":"Crossref","is-referenced-by-count":86,"title":["Long\u2010term administration of ddt or phenobarbital\u2010na in wistar rats"],"prefix":"10.1002","volume":"19","author":[{"given":"Lorenzo","family":"Rossiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Ravera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Repetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Santi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4735.819"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb46897.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(67)90030-0"},{"key":"e_1_2_1_5_1","first-page":"345","article-title":"Hyperplastic liver nodules","volume":"7","author":"Farber E.","year":"1973","journal-title":"Methods Cancer Res."},{"key":"e_1_2_1_6_1","first-page":"18","article-title":"Chronic oral toxicity of DDT","volume":"89","author":"Fitzhugh O. 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