{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:34:24Z","timestamp":1699835664226},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":10716,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1977,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral blood lymphocytes from 20 patients with acute infectious mononucleosis (IM) were studied for cell aggregation and for cap formation by concanavalin A (Con A). The lymphocytes from these patients showed 5.2\u00b11.5% cells with a Con\u2010A\u2010induced cap and a high degree of cell aggregation without Con A, compared to 27.7\u00b13.2% caps and a low degree of cell aggregation with normal lymphocytes. The lymphocytes from IM patients were fractionated to enrich for T and B cells. There was a low frequency of cap formation in both T and B cells, but the high degree of cell aggregation without Con A only occurred with B cells. Studies with four patients in clinical remission from acute IM have shown that the frequency of Con\u2010A\u2010induced cap formation only returned to normal more than 3 months after the beginning of clinical remission and that even at 6 months the cells still showed a high degree of cell aggregation. The results indicate that a high degree of B\u2010cell aggregation and a low percentage of B and T cells with a Con\u2010A\u2010induced cap were associated with acute IM and that the changes associated with a high degree of B\u2010cell aggregation were by themselves not sufficient to cause the disease.<\/jats:p>","DOI":"10.1002\/ijc.2910190310","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:25:43Z","timestamp":1171902343000},"page":"345-350","source":"Crossref","is-referenced-by-count":5,"title":["Surface membrane changes in lymphocytes from patients with infectious mononucleosis"],"prefix":"10.1002","volume":"19","author":[{"given":"Uri","family":"Mintz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910140310"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170406"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.132.4.702"},{"key":"e_1_2_1_5_1","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"97","author":"B\u00f6yum A.","year":"1968","journal-title":"Scand. 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