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After 5 to 6 months, extrauterine tumors were observed in 80% of the operated rats, and elevated serum \u03b1\u2010fetoprotein levels were detected in 80% of the tumor\u2010bearing rats. The tumors in AFP\u2010positive rats always contained yolk\u2010sac tumor elements. In transplantable tumor lines established in the ascites form, numerous free\u2010floating embryoid bodies were observed. The experiments demonstrate that yolk\u2010sac tumors (endodermal sinus tumors) can be induced by simple fetectomy without infection by exogenous tumor virus.<\/jats:p>","DOI":"10.1002\/ijc.2910200114","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:31:49Z","timestamp":1171902709000},"page":"83-86","source":"Crossref","is-referenced-by-count":24,"title":["Experimental yolk\u2010sac tumors produced by fetectomy without virus infection in rats"],"prefix":"10.1002","volume":"20","author":[{"given":"Shigeo","family":"Sakashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidematsu","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/228995a0"},{"key":"e_1_2_1_3_1","first-page":"215","article-title":"Yolk sac tumor and \u03b1\u2010fetoprotein: clinicopathological study of four cases","volume":"65","author":"Iyoh T.","year":"1974","journal-title":"Gann"},{"key":"e_1_2_1_4_1","first-page":"303","volume-title":"Protides of the biological fluids\u201423rd colloquium","author":"Nishi S.","year":"1975"},{"key":"e_1_2_1_5_1","first-page":"106","article-title":"Placental grafts in rats","volume":"9","author":"Payne J. 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