{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:40:45Z","timestamp":1766266845356},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":10564,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1977,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The sensitivity of cultured fibroblasts obtained from four unrelated <jats:italic>Xeroderma pigmentosum<\/jats:italic> patients (XP\u2010K, XP\u2010C, XP\u2010E and XP\u2010H), which showed different DNA repair levels, was examined. The frequency of metaphase plates with chromosome aberrations and the frequency of breaks and exchanges per chromosome complement were estimated following exposure to the carcinogens 4\u2010nitroquinoline\u20101\u2010oxide (4N QO), N\u2010acetoxy\u20102\u2010acetyl\u2010aminofluorene (N\u2010acetoxy\u20102\u2010AAF), and N\u2010methyl\u2010N\u2032\u2010nitro\u2010N\u2010nitrosoguanidine (MNNG), and to the mutagen daunomycin. The frequency of chromosome aberrations (breaks and exchanges) increased in the order (XP\u2010K &lt; XP\u2010C &lt; XP\u2010E &lt; XP\u2010H) with decreasing DNA repair capacity of the XP cells examined (XP\u2010K &gt; XP\u2010C &gt; XP\u2010E &gt; XP\u2010H) following 4N QO and N\u2010acetoxy\u20102\u2010AAF. MNNG induced DNA repair synthesis and chromosome aberrations in the four XP cell types at levels comparable to those in fibroblasts of non\u2010afflicted persons. Daunomycin triggered no DNA repair synthesis but induced similar frequencies of chromosome aberrations in the XP cells and controls. Heterozygous XP cells from parents of XP\u2010K, XP\u2010E and XP\u2010C responded as control cells towards the three carcinogens and the mutagen used. <jats:italic>Xeroderma pigmentosum<\/jats:italic> can be considered to be an \u201cinduced\u201d chromosome instability syndrome, in contrast to Bloom's syndrome or Fanconi's anaemia, which are \u201cspontaneous\u201d chromosome breakage syndromes according to German's definition.<\/jats:p>","DOI":"10.1002\/ijc.2910200204","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:25:50Z","timestamp":1171905950000},"page":"181-187","source":"Crossref","is-referenced-by-count":21,"title":["Differential sensitivity of <i>Xeroderma pigmentosum<\/i> cells of different repair capacities towards the chromosome breaking action of carcinogens and mutagens"],"prefix":"10.1002","volume":"20","author":[{"given":"R. H. C.","family":"San","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Stich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. F.","family":"Stich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(65)90539-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.11.4508"},{"key":"e_1_2_1_4_1","first-page":"52","article-title":"The repair of X\u2010ray\u2010induced chromosomal damage in trisomy\u201021 and normal diploid lymphocytes","volume":"37","author":"Countryman P. 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