{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:37:54Z","timestamp":1759333074215},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":10563,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1977,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The presence of alien histocompatibility antigens on the cell surface of the 3\u2010methylcholanthreneinduced BALB\/c (H\u20102<jats:sup>d<\/jats:sup>) fibrosarcoma C\u20101, was investigated by serological and transplantation studies. Absorption experiments with monospecific alloantisera showed that C\u20101 cells expressed their original private (H\u20102.4 and 31) and public (H\u20102.3, 8, 28, and 35) specificities. C\u20101 cells were also able to absorb monospecific antisera directed to the private specificity H\u20102.23 of the H\u20102<jats:sup>k<\/jats:sup> haplotype, as well as antisera to the public specificities H\u20102.1, 5, 11 and 25 (H\u20102<jats:sup>k<\/jats:sup> and in part H\u20102<jats:sup>q<\/jats:sup>, H\u20102<jats:sup>a<\/jats:sup> and H\u20102<jats:sup>b<\/jats:sup> haplotypes), which are absent from H\u20102<jats:sup>d<\/jats:sup> normal cells. Conversely, other alien specificities (H\u20102.2, 17, 30, 32, and 33) were not detected on C\u20101 cells. The C\u20101 cells were also unable to absorb the activity of an anti\u2010la serum (1\u201328) directed to la.1, 2 and 19 (la<jats:sup>k<\/jats:sup>) specificities. Transplantation studies showed that resistance against the challenge of C\u20101 cells could be induced in syngeneic BALB\/c mice by preimmunization with normal tissues from C3Hf and AKR (H\u20102<jats:sup>k<\/jats:sup>), A (H\u20102<jats:sup>a<\/jats:sup>) and C57BL\/6J (H\u20102<jats:sup>b<\/jats:sup>) strains (expressing all or some of the extra H\u20102 antigens of the tumor) whereas no protection was obtained with DBA\/2 (H\u20102<jats:sup>d<\/jats:sup>) or with W\/Fu rat tissues. The anti\u2010tumor activity could be passively transferred by BALB\/c lymphoid cells immune to normal C3Hf, AKR, A, and NIH (H\u20102<jats:sup>q<\/jats:sup>) tissues, but no protection was achieved with lymphoid cells immune to DBA\/2 or to W\/Fu normal rat tissues. These data indicate that foreign H\u20102 antigens are expressed on C\u20101 tumor and that they might function as tumor\u2010associated transplantation antigen which was shown to be present and individually distinct on this sarcoma by appropriate <jats:italic>in vivo<\/jats:italic> tests.<\/jats:p>","DOI":"10.1002\/ijc.2910200216","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:25:50Z","timestamp":1171905950000},"page":"271-283","source":"Crossref","is-referenced-by-count":49,"title":["Expression of alien h\u20102 specificities on a chemically induced balb\/c fibrosarcoma"],"prefix":"10.1002","volume":"20","author":[{"given":"Angela","family":"Meschini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Invernizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Parmiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2458","article-title":"Search for common antigenicities among twenty\u2010five sarcomas induced by methylcholanthrene","volume":"30","author":"Basombr\u00edo M. 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