{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:40:11Z","timestamp":1766266811428},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":10563,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1977,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A single SC injection of 2\u2010acetylaminofluorene (AAF) was given to pregnant C57BL\/6 mice on day 15 of gestation, and the offspring subsequently given twice\u2010weekly injections of phorbol for 25 weeks. Control groups included: (1) untreated; (2) AAF\u2010treated mothers (kept under observation for 18 months, as with all the other groups); (3) untreated offspring of untreated mothers; (4) untreated offspring of AAF\u2010treated mothers, and (5) phorboltreated offspring of untreated mothers. The incidence of hepatomas in the phorbol\u2010treated offspring of AAF\u2010injected mothers was 8\/74 (11%), as compared with 2\/80 (2.5%) in the untreated offspring of AAF\u2010injected mothers. The AAF\u2010injected mothers themselves developed 3\/36 (8%) hepatomas; while all the other control groups were free from liver tumours. The development of reticulum cell sarcomas, and of a few cases of lung adenomas, in the various groups, was presumably spontaneous. The results seem sufficiently encouraging, as a model for the study of systemic carcinogenesis, to warrant further attempts at two\u2010stage transplacental carcinogenesis, using other potential initiators and promoters.<\/jats:p>","DOI":"10.1002\/ijc.2910200218","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:25:50Z","timestamp":1171905950000},"page":"292-295","source":"Crossref","is-referenced-by-count":15,"title":["Possible two\u2010stage transplacental liver carcinogenesis in c57bl\/6 mice"],"prefix":"10.1002","volume":"20","author":[{"given":"Vlasta","family":"Armuth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Berenblum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1976.206"},{"key":"e_1_2_1_3_1","first-page":"2259","article-title":"Systemic promoting action of phorbol in liver and lung carcinogenesis in AKR mice","volume":"32","author":"Armuth V.","year":"1972","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","first-page":"2704","article-title":"Promotion of mammary carcinogenesis and leukemogenic action by phorbol in virgin female Wistar rats","volume":"34","author":"Armuth V.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_1","first-page":"323","volume-title":"Cancer","author":"Berenblum I.","year":"1975"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-135-34993"},{"key":"e_1_2_1_7_1","first-page":"2338","article-title":"Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae","volume":"28","author":"Hecker E.","year":"1968","journal-title":"Cancer Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1948.35"},{"key":"e_1_2_1_9_1","first-page":"2254","article-title":"Two\u2010stage chemical oncogenesis in cultures of C3H\/10T1\/2 cells","volume":"36","author":"Mondal S.","year":"1976","journal-title":"Cancer Res."},{"key":"e_1_2_1_10_1","series-title":"IARC Scientific Publications, No. 4","volume-title":"Transplacental carcinogenesis","author":"Napalkov N. P.","year":"1973"},{"key":"e_1_2_1_11_1","first-page":"84","article-title":"Orally administered 2\u2010acetylaminofluorene as an initiator and as a promoter in epidermal carcinogenesis in the mouse","volume":"15","author":"Ritchie A. C.","year":"1955","journal-title":"Cancer Res."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1967.42"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60415-7"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910200218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910200218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T16:24:05Z","timestamp":1699806245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910200218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8,15]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,8,15]]}},"alternative-id":["10.1002\/ijc.2910200218"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910200218","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,8,15]]}}}