{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:11:20Z","timestamp":1699834280752},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":10502,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1977,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010three patients with recent infectious mononucleosis were studied for cell\u2010mediated immunity to Epstein\u2010Barr virus (EBV)\u2010associated antigens. By means of a virion\u2010containing antigen preparation, (P3J), leukocyte migration inhibition was demonstrated in 6 of 13 patients with acute infectious mononucleosis (IM) and in 6 of 10 patients studied during the convalescent period. Inhibition with a soluble antigen (S) preparation was seen in only a few patients at all stages of the illness. Lymphocyte blast transformation on exposure to P3J occurred in 4 of 9 patients with acute IM; no other study group reacted. Control donors lacking anti\u2010EBV antibodies did not demonstrate migration inhibition or blast transformation with either P3J or S. Control donors with evidence of previous EBV infection did demonstrate migration inhibition with P3J (8 of 12) and S (3 of 10). These studies indicated that cell\u2010mediated immunity to EBV\u2010associated antigens could be detected by either leukocyte migration inhibition or lymphocyte blast transformation, but neither assay is diagnostic of infectious mononucleosis.<\/jats:p>","DOI":"10.1002\/ijc.2910200406","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:06:24Z","timestamp":1171904784000},"page":"506-511","source":"Crossref","is-referenced-by-count":13,"title":["Cell mediated immunity during infectious mono\u2010nucleosis to epstein\u2010barr virus associated antigens"],"prefix":"10.1002","volume":"20","author":[{"given":"Phillip","family":"Periman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. H.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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