{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:05:51Z","timestamp":1762067151750},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":10379,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1978,2,15]]},"abstract":"Abstract<\/jats:title>Natural cell\u2010mediated cytotoxicity in rats as well as in mice has been shown to vary consistently with age, with peak levels detectable at 5\u201310 weeks. The levels of cell\u2010mediated cytotoxicity against tumor cells could be augmented in strains of inbred rats with either high or low levels of natural reactivity, by IP injection of a variety of agents, including C. parvum<\/jats:italic>3<\/jats:sup>, LCMV, KRV, and poly I:C. The specificity of the augmented cytotoxicity appeared to be the same as the specificity of natural killer cells which are found in normal rat spleen cells. Similarly, the cells mediating the augmented cellular cytotoxicity were small, non\u2010adherent, esterase\u2010negative lymphocytes with Fc receptors, as are rat NK cells. The kinetics and organ distribution of the augmentation of NK activity by poly I:C and C. parvum<\/jats:italic> were compared and the kinetics were found to differ, with a shorter time course of augmented activity seen after inoculation with poly I:C. These data indicate that interferon may play a central role in the augmentation of NK activity in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910210213","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:03:41Z","timestamp":1171904621000},"page":"210-220","source":"Crossref","is-referenced-by-count":108,"title":["Natural cell\u2010mediated cytotoxicity in rats. II. In vivo<\/i> augmentation of NK\u2010cell activity"],"prefix":"10.1002","volume":"21","author":[{"given":"J. Ronald","family":"Oehler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leroy R.","family":"Lindsay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrthel E.","family":"Nunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard T.","family":"Holden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B.","family":"Herberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/224372a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1973.35"},{"key":"e_1_2_1_4_1","first-page":"418","article-title":"Synthetic poly\u2010nucleotides as restorers of normal antibody forming capacities in aged mice","volume":"7","author":"Braun W.","year":"1970","journal-title":"J. reticuloendothel. Soc."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/228071a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.21.020170.000313"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(74)90068-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.58.3.1004"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.63.1.51"},{"key":"e_1_2_1_10_1","first-page":"77","article-title":"Stimulation de l'activit\u00e9 phagocytaire du syst\u00e8me r\u00e9ticuloendoth\u00e9lial provoqu\u00e9e par Corynebacterium parvum","volume":"1","author":"Halpern B. N.","year":"1963","journal-title":"J. reticuloendothel. Soc."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910160512"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4049\/jimmunol.119.1.322","article-title":"Fc receptors on mouse effector cells mediating natural cytotoxicity against tumor cells","volume":"119","author":"Herberman R. B.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_13_1","volume-title":"Advances in Cancer Research","author":"Herberman R. B."},{"key":"e_1_2_1_14_1","first-page":"489","volume-title":"In vitro methods in cell mediated and tumor immunity","author":"Herberman R. B.","year":"1976"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190417"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.180.4088.868"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4049\/jimmunol.112.3.1231","article-title":"Cellular immunoabsorbents. A simplified technique for separation of lymphoid\u2010cell populations","volume":"112","author":"Kedar E. M.","year":"1974","journal-title":"J. Immunol."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830050209"},{"key":"e_1_2_1_19_1","first-page":"735","article-title":"Malignant lymphomas of extrathymic origin induced in rats by murine erythroblastosis virus","volume":"43","author":"Kirsten W. H.","year":"1969","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.62.2.357"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.3.721"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.143.1.225"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040730305"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/56.2.393"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(77)90118-6"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(77)90319-7"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910210212"},{"key":"e_1_2_1_28_1","first-page":"147","article-title":"Immune response to a Gross\u2010virus\u2010induced lymphoma. III. Characteristics of the cellular immune response","volume":"49","author":"Ortiz De Landazuri M.","year":"1972","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1970.tb53476.x"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-136-35304"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910140109"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190212"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190211"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","unstructured":"Welsh R. M. Jr. andZinkernagel R. M. Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice.Nature (Lond.) in press (1977).","DOI":"10.1038\/268646a0"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4049\/jimmunol.118.1.355","article-title":"Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: characterization of effector cells","volume":"118","author":"West W. H.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197703000-00013"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/262584a0"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-130-33503"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910210213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910210213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T05:10:11Z","timestamp":1699765811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910210213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,2,15]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1978,2,15]]}},"alternative-id":["10.1002\/ijc.2910210213"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910210213","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,2,15]]}}}