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Epithelial cell islands from fibro\u2010adenomas and from normal lacteal secretions completely excluded the fibroblasts, and individual cell territories were maintained even in dense cultures. Electron microscopy of the boundary between epithelium and fibroblasts showed that the two cell types made contact. In contrast, epithelial islands from two carcinomas did not retain territorial integrity and allowed penetration of mammary fibroblasts. Confronting homologous epithelial islands from benign tumours merged, but this was shown to be due to interdigitation rather than free mixing of cells. Epithelial cells moved actively but unlike fibroblasts they retained their neighbour relationships.<\/jats:p>","DOI":"10.1002\/ijc.2910210304","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:01:13Z","timestamp":1171904473000},"page":"268-273","source":"Crossref","is-referenced-by-count":11,"title":["Movement of human mammary tumour cells in culture: Exclusion of fibroblasts by epithelial territories"],"prefix":"10.1002","volume":"21","author":[{"given":"M. G. 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Shearer M. andTilly R. Further studies on growth requirements of human mammary epithelial cells in culture.Int. J. Cancer submitted for publication (1978)."},{"key":"e_1_2_1_11_1","first-page":"1641","article-title":"The in vitro interaction of intraepithelial neoplasia, normal epithelium and fibroblasts from the adult human uterine cervix","volume":"26","author":"Wilbanks G. D.","year":"1966","journal-title":"Cancer Res."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910210304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910210304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T06:12:25Z","timestamp":1699769545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910210304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,3,15]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,3,15]]}},"alternative-id":["10.1002\/ijc.2910210304"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910210304","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,3,15]]}}}