{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:09:59Z","timestamp":1791202199840,"version":"4.2.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":10229,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1978,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A cohort of 9,454 patients with infectious mono\u2010nucleosis, serologically confirmed, was followed up to determine their risk of developing lymphopro\u2010liferative diseases. A total of 1,759 patients was identified in Scotland from 1959 to 1971 and 7,695 in Sweden from 1952 to 1970. The cancer cases were identified by matching the list of patients with infectious mononucleosis against a list of patients with lymphoma, nasopharyngeal and colon carcinomas registered through 1972 in Sweden and through 1973 in Scotland. A four\u2010fold increase in risk was found for Hodgkin's disease based on 7 cases observed against 1.8 expected. Most of the excess cases of Hodgkin's disease occurred within three years of the diagnosis of infectious mononucleosis and among females. These results are similar to those of four other cohort studies and it is concluded that a positive association exists between infectious mononucleosis and Hodgkin's disease. Several explanations of this association were evaluated. Firstly, it may be that a very small proportion of persons who are in the course of developing Hodgkin's disease are temporarily misdiagnosed as having infectious mononucleosis. Secondly, infectious mononucleosis may increase the susceptibility to a factor which causes or promotes the development of Hodgkin's disease. Thirdly, infectious mononucleosis and Hodgkin's disease may share a common aetiology. Arguments in favour of, or against, each of these explanations are presented.<\/jats:p>","DOI":"10.1002\/ijc.2910220104","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:23:48Z","timestamp":1171905828000},"page":"10-13","source":"Crossref","is-referenced-by-count":103,"title":["Infectious mononucleosis and Hodgkin's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"N.","family":"Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J. L.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Witthoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Ericsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"De\u2010Th\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/oxfordjournals.aje.a112352","article-title":"Cancer incidence following infectious mononucleosis","volume":"105","author":"Carter C. D.","year":"1977","journal-title":"Amer. J. Epidem."},{"key":"e_1_2_1_3_1","first-page":"1172","article-title":"A cohort study of cancer following infectious mononucleosis","volume":"34","author":"Connelly R. R.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","first-page":"225","volume-title":"Infectious mononucleosis","author":"Dameshek W.","year":"1969"},{"key":"e_1_2_1_5_1","series-title":"IARC Scientific Publication No. 2","first-page":"376","volume-title":"Oncogenesis and herpesviruses","author":"Davidson R. J. L.","year":"1972"},{"key":"e_1_2_1_6_1","first-page":"1196","article-title":"Nasopharyngeal carcinoma: recent studies and outlook for a viral etiology","volume":"34","author":"De\u2010Th\u00e9 G.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_1","series-title":"IARC Scientific Publication No. 2","first-page":"351","volume-title":"Oncogenesis and herpesviruses","author":"Evans A. S.","year":"1972"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190502"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/jnci\/50.2.315","article-title":"Infectious mononucleosis and the empirical risk of cancer","volume":"50","author":"Miller R. W.","year":"1973","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5913.253"},{"key":"e_1_2_1_11_1","first-page":"754","article-title":"False\u2010positive infectious mononucleosis spot test in lymphoma","volume":"52","author":"Wolf P.","year":"1969","journal-title":"Amer. J. clin. Path."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910220104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910220104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T04:34:55Z","timestamp":1699763695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910220104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,7,15]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,7,15]]}},"alternative-id":["10.1002\/ijc.2910220104"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910220104","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,7,15]]}}}