{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:51Z","timestamp":1760188851920},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":10198,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1978,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 12\u2010year\u2010old patient with acute lymphoblastic leukemia received a bone\u2010marrow transplant (BMT) from a matched sibling donor. Nine weeks prior to transplant the donor experienced Epstein\u2010Barr virus (EBV)\u2010induced infectious mononucleosis. The bone\u2010marrow recipient was EBV\u2010negative at the time of transplant; however, 4 weeks post transplant the recipient developed clinical symptoms of graft\u2010versus\u2010host disease (GVHD) coincident with serological evidence of acute EBV infection. In addition, a lymphoblastoid cell line positive for Epstein\u2010Barr nuclear antigen was established from a bone\u2010marrow sample obtained at the onset of symptoms compatible with GVHD. Sera obtained from the recipient over the ensuing 2 months showed the appearance of antibodies to specific EBV antigens consistent with a primary immune response to EBV infection. This association of acute EBV infection with symptoms of GVHD in a BMT recipient suggests a need for further investigation of the epidemiology of EBV infections in human bone\u2010marrow transplantation and the relationship between EBV infection and GVHD.<\/jats:p>","DOI":"10.1002\/ijc.2910220205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:22:49Z","timestamp":1171905769000},"page":"132-135","source":"Crossref","is-referenced-by-count":14,"title":["Epstein\u2010barr virus infection following bone\u2010marrow transplantation"],"prefix":"10.1002","volume":"22","author":[{"given":"John L.","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Wallen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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