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This antigen is revealed by indirect immunofluorescence and shows no detectable cross\u2010antigenicity with EBNA or any other known EBV\u2010associated antigen. EBV\u2010isolates from P3HR\u20101 cells fail to induce a similar antigen in Ramos cells although they induce EBNA. No RAM\u2010ag was expressed, either after infection of cells of another EBV\u2010genome\u2010negative human B\u2010lymphoma line BJAB with B95\u20108 EBV or in a series of EBV\u2010harbouring cell lines. Thus the antigen appears to be cell\u2010line\u2010specific for Ramos cells. It is also induced upon infection of either B95\u20108 or P3HR\u20101 converted Ramos sublines with EBV from B95\u20108 cells. All human sera with RAM\u2010ag\u2010reactivity revealed antibodies against VCA. However, sera from patients with acute infectious mononucleosis containing high anti\u2010VCA\u2010antibodies did not react with RAM\u2010ag. Seroconversion for this antigen apparently more closely coincides with the appearance of EBNA\u2010directed antibodies.<\/jats:p>","DOI":"10.1002\/ijc.2910220209","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:22:49Z","timestamp":1171905769000},"page":"160-165","source":"Crossref","is-referenced-by-count":8,"title":["Heterogeneity of epstein\u2010barr virus. IV. Induction of a specific antigen by EBV from two transformed marmoset cell lines in ramos cells"],"prefix":"10.1002","volume":"22","author":[{"given":"K.\u2010O.","family":"Fresen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010S.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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