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The incidence and geometric mean titers of IgG antibodies to viral capsid antigen (VCA) in the HD patients at the time of diagnosis and in the controls were similar. The anti\u2010VCA titers of the patients rose above control levels during and after therapy and remained elevated for up to 7 years of observation. At no time were heterophil or VCA\u2010specific IgM antibodies detected. Antibodies to EBV\u2010induced early antigens were more common in patients (ultimately 80%) than in controls (9%). In contrast, antibody levels to EBV\u2010associated nuclear antigen were disproportionally low in the patients. Excretion of EBV was noted at increased frequency in the patients but the number of circulating, EBV\u2010carrying lymphoid cells was the same as in controls. No discrete clinical syndrome was associated with rising antibody titers or viral excretion. While these results are best explained by a presumed reactivation of the persistent EBV infection by immunosuppressive effects of HD or its therapy, they have not provided direct evidence for this suggestion.<\/jats:p>","DOI":"10.1002\/ijc.2910220503","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:19:18Z","timestamp":1171905558000},"page":"521-527","source":"Crossref","is-referenced-by-count":43,"title":["Longitudinal study of epstein\u2010barr virus antibody titers and excretion in pediatric patients with Hodgkin's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Beverly","family":"Lange","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Arbeter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hewetson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Henle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Berkel A. 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