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This phenomenon, known as the \u201c6\u2010hour T\u2010cell response\u201d is abrogated when small tumour cell inocula (10<jats:sup>2<\/jats:sup>), or small amounts of a preparation from tumour cells, which contains tumour antigens, are injected prior to the immunogenic challenge Abrogation of the \u201c6\u2010hour T\u2010cell response\u201d resulted in a decrease in specific anti\u2010tumour cell immunity as tested <jats:italic>in vitro<\/jats:italic> by measuring growth inhibition (cytostasis). It has also resulted in loss of the amplifying function on antibody formation against sheep erythrocytes, normally detected in a T\u2010B cell co\u2010operative system when T cells are used 6 h after priming with sheep erythrocytes. It is postulated that this T\u2010cell defect may represent a mechanism by which tumour cells, in the early stages of their growth, interfere with inductive stages of the immune response for a sufficient period of time to allow the tumour to grow beyond immune control.<\/jats:p>","DOI":"10.1002\/ijc.2910220518","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:19:18Z","timestamp":1171905558000},"page":"621-629","source":"Crossref","is-referenced-by-count":3,"title":["Surface membrane changes of T cells induced by syngeneic tumour cells. II. T\u2010cell defects induced by small tumour cell inocula or tumour cell antigens"],"prefix":"10.1002","volume":"22","author":[{"given":"D. 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