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The families had: malignant melanoma; Epstein\u2010Barr virus\u2010associated malignancies and a birth defect syndrome; non\u2010Hodgkin lymphoma and diverse carcinomas; Hodgkin's lymphoma and adenocarcinomas; and acute myelogenous leukemia. In addition to the Philadelphia chromosome in chronic myelogenous leukemia patients, karyotypic abnormalities, especially breaks and fragments, were found in 29% of cancer family members, but were inconsistent and usually attributable to radiotherapy. Mean sister chromatid exchange values were normal in chronic myelogenous leukemia, but low (by t\u2010test) in tumor patients and their blood relatives in cancer\u2010prone families. In tumor patients, mean sister chromatid exchange levels fell as age increased. After adjusting for this age effect, no significant differences remained among groups. In patients at high risk of cancer (because they have chronic myelogenous leukemia or a strong family history of cancer), spontaneous sister chromatid exchange rates were not a marker of cancer risk.<\/jats:p>","DOI":"10.1002\/ijc.2910230103","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:14:28Z","timestamp":1171905268000},"page":"8-13","source":"Crossref","is-referenced-by-count":36,"title":["Sister chromatid exchanges and chromosomes in chronic myelogenous leukemia and cancer families"],"prefix":"10.1002","volume":"23","author":[{"given":"Wind\u2010Show","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Mulvihill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda W.","family":"Pickle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shien","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Whang\u2010Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1976.tb00166.x"},{"key":"e_1_2_1_3_1","first-page":"126","article-title":"Sister chromatid exchange (SCE) in lymphocytes from patients with malignant lymphomas","volume":"19","author":"Bloomfield C. 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