{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:45:26Z","timestamp":1763358326401},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9955,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1979,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The reproducibility and immunological specificity of the tumor \u201csneaking through\u201d phenomenon and enhancement of tumor growth were studied in syngeneic and random\u2010bred Syrian hamsters by means of a quantitative modification of the transplantation test. After primary challenge the phenomenon was neither observed in normal animals nor in animals effectively immunized against tumor. However, it was regularly observed in some \u201cimmune\u201d animals after secondary challenge. In primary challenge of animals \u201csneaking through\u201d phenomenon was most often observed in animals pretreated with large doses of heat\u2010inactivated tumor cells. This characteristic could not be transferred with serum of pretreated animals. In contrast to specific tumor immunity, the \u201csneaking through\u201d phenomenon appeared to be immunologically non\u2010specific. This was observed in cross\u2010transplantation tests with tumor cells bearing different TSTAs. Thus, TSTA is not an inducer and apparently not a target for a response leading to enhancement of tumor growth in pretreated hamsters. Experiments demonstrating enhanced tumor growth in pretreated animals at the same time demonstrate two other possibly more essential findings: (1) normal animals are naturally resistant to transplantation of 1 to about 1 \u00d7 10<jats:sup>3<\/jats:sup> (or more) tumor cells; and (2) this resistance can be totally abrogated by the pretreatment of normal animals with tumor cell preparations. The preliminary data demonstrate that abrogation of natural anti\u2010tumor resistance in adult hamsters subsequently inoculated with SV40 leads to rapid development of primary tumors in such animals. The development of specific anti\u2010tumor immune response in animals treated with inactivated tumor cell preparations was also studied. Significant non\u2010specific inhibition of primary and secondary anti\u2010tumor immune response in Syrian hamsters treated with inactivated syngeneic tumor cells was observed. The data obtained are considered to demonstrate two anti\u2010tumor defense systems in the animal, i. e., nonspecific natural resistance and specific anti\u2010tumor immunity. The first seems to be responsible for elimination of low numbers of tumor cells in the normal organism and also to be essential for effective induction and functioning of the specific anti\u2010tumor immunity.<\/jats:p>","DOI":"10.1002\/ijc.2910230420","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:48:01Z","timestamp":1171907281000},"page":"571-584","source":"Crossref","is-referenced-by-count":12,"title":["Reproducibility and relation to specific and non\u2010specific anti\u2010tumor resistance of the tumor \u201csneaking through\u201d phenomenon"],"prefix":"10.1002","volume":"23","author":[{"given":"G. I.","family":"Deichman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. E.","family":"Kluchareva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Kashkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. A.","family":"Matveeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"259","volume-title":"Cancer invasion and metastasis: biological mechanisms and therapy","author":"Alexander P.","year":"1977"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/53.2.475"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000386035"},{"key":"e_1_2_1_5_1","first-page":"3","article-title":"Immunological surveillance in neoplasia","volume":"7","author":"Burnet M. F.","year":"1971","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-80-19708"},{"key":"e_1_2_1_7_1","first-page":"337","volume-title":"Onco\u2010developmental gene expression","author":"Deichman G. I.","year":"1976"},{"key":"e_1_2_1_8_1","first-page":"295","article-title":"Specific and nonspecific activation of macro\u2010phages: significance in tumor immunity","volume":"28","author":"Evans R.","year":"1974","journal-title":"Fogarty Intern. Center Proc."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-4-109"},{"key":"e_1_2_1_10_1","first-page":"17","article-title":"Cell marker studies of human lumorigenesis","volume":"28","author":"Friedman J. M.","year":"1976","journal-title":"Transplant Rev."},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.4049\/jimmunol.116.3.791","article-title":"Regulation of the immune response to tumor antigens. I. Immunosup\u2010pressor cells in tumor\u2010bearing host","volume":"116","author":"Fujimoto S.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.1.436"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60936-7"},{"key":"e_1_2_1_14_1","first-page":"223","article-title":"Role of activated macrophages in nonspecific resistance to neoplasia","volume":"20","author":"Hibbs J. B.","year":"1976","journal-title":"J. reticuloendothel. Soc."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910130511"},{"key":"e_1_2_1_16_1","first-page":"165","volume-title":"The specificity of cell surfaces","author":"Klein G.","year":"1967"},{"key":"e_1_2_1_17_1","first-page":"71","volume-title":"Immunological surveillance against neoplasia. Harvey Lect","author":"Klein G.","year":"1975"},{"key":"e_1_2_1_18_1","first-page":"203","volume-title":"Immunology of tumor\u2010host relationship","author":"Klein G.","year":"1975"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/jnci\/52.5.1393","article-title":"Immune surveillance revised","volume":"52","author":"Kripke M. L.","year":"1974","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_20_1","first-page":"258","article-title":"Thermosensitivity of tumor specific transplantation antigens on the cell membrane","volume":"3","author":"Kluchareva T. E.","year":"1978","journal-title":"Bull. exp. Biol. Med."},{"key":"e_1_2_1_21_1","first-page":"273","article-title":"Sensitivity of TSTA and species\u2010specific antigens of tumor cells to glutaraldehyde treatment","volume":"25","author":"Kluchareva T. E.","year":"1978","journal-title":"Neoplasma"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/jnci\/59.3.769","article-title":"Stimulation of tumor cell growth in vitro: a critical evolution of immunological specificity","volume":"59","author":"Lamon E. W.","year":"1977","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/243083a0"},{"key":"e_1_2_1_24_1","first-page":"442","article-title":"Studies on heat\u2010stable accelerant from transplanted and spontaneous mammary tumors in mice","volume":"15","author":"Martinez C.","year":"1955","journal-title":"Cancer Res."},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1093\/jnci\/54.6.1349","article-title":"Protective tumor immunity induced by potassium chloride extracts of guinea pig hepatomas","volume":"54","author":"Meltzer M. S.","year":"1974","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_26_1","first-page":"437","article-title":"Acceleration in the transplantation and killing time of mammary tumors in mice pretreated with a heat\u2010stable tumor preparation","volume":"15","author":"Miroff G.","year":"1955","journal-title":"Cancer Res."},{"key":"e_1_2_1_27_1","first-page":"11","article-title":"Modified technique for determination of the sensitivity of hamsters to transplantation of tumor cells","volume":"12","author":"Murka L. M.","year":"1965","journal-title":"Bull. exp. Biol. Med."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1962.tb26446.x"},{"key":"e_1_2_1_29_1","first-page":"1","article-title":"Spontaneous and induced tumor incidence in germfree \u201enude\u201d\ufe01 mice","volume":"17","author":"Outzen H. C.","year":"1975","journal-title":"J. reticuloendothel. Soc."},{"key":"e_1_2_1_30_1","first-page":"1205","article-title":"Specific depression of the antitumor cellular immune response with autologous tumor homogenate","volume":"35","author":"Paranjpe M. S.","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.4049\/jimmunol.117.4.1243","article-title":"Depression of macrophage function by a factor produced by neoplasms: a mechanism for abrogation of immune surveillance","volume":"117","author":"Pike M. C.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.5.1848"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.176.4031.170"},{"key":"e_1_2_1_34_1","first-page":"34","article-title":"Do tumors grow because of the immune response of the host?","volume":"28","author":"Prehn R. T.","year":"1976","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_35_1","first-page":"43","article-title":"The nude mice vs. the hypothesis of immunological surveillance","volume":"28","author":"Rygaard J.","year":"1976","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.4049\/jimmunol.118.5.1517","article-title":"Characteristics of the immature cells involved in T\u2010cell\u2010mediated enhancement of syngeneic tumor growth","volume":"118","author":"Small M.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_37_1","first-page":"1384","article-title":"Specific enhancement of tumor growth and depression of cell mediated immunity following sensitization to soluble tumor antigens","volume":"36","author":"Srinivasa R. V.","year":"1976","journal-title":"Cancer Res."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-123-31558"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197409000-00007"},{"key":"e_1_2_1_40_1","first-page":"1655","article-title":"Concomitant immunity and specific depression of immunity by residual or reinjected syngeneic tumor tissue","volume":"31","author":"Vaage I.","year":"1971","journal-title":"Cancer Res."},{"key":"e_1_2_1_41_1","first-page":"193","article-title":"Specific desensitization of resistance against a syngeneic methylcholanthrene\u2010induced sarcoma in C3Hf mice","volume":"32","author":"Vaage I.","year":"1972","journal-title":"Cancer Res."},{"key":"e_1_2_1_42_1","first-page":"178","volume-title":"Tarasevich Memorial Scientifique Conference","author":"Vasilieva N. N.","year":"1964"},{"key":"e_1_2_1_43_1","first-page":"195","article-title":"Abrogation of passively transferred tumor immunity in vivo by antigenically related tumor cells","volume":"46","author":"Wepsic H. T.","year":"1971","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910130413"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910230420","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910230420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T09:33:03Z","timestamp":1699781583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910230420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,4,15]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,4,15]]}},"alternative-id":["10.1002\/ijc.2910230420"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910230420","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,4,15]]}}}