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The same blood specimens from four of the five patients contained cells that formed EBNA\u2010positive colonies in soft agar containing EBV antibodies. The ratio of the colony formers to EBNA\u2010positive cells was higher in blood samples taken early in the disease than in those obtained in later stages of the disease. The present results strongly suggest that EBV\u2010transformed cells are present in the peripheral circulation of IM patients and that such cells can directly give rise to immortalized cetl lines in vitro.<\/jats:p>","DOI":"10.1002\/ijc.2910230603","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:45:55Z","timestamp":1171907155000},"page":"746-750","source":"Crossref","is-referenced-by-count":27,"title":["Simultaneous presence of EBNA\u2010positive and colony\u2010forming cells in peripheral blood of patients with infectious mononucleosis"],"prefix":"10.1002","volume":"23","author":[{"given":"T.","family":"Katsuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hinuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hirashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sudoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Motokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1781","article-title":"Studies of surface immunoglobulins on human B lymphocytes. 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