{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:17:28Z","timestamp":1791429448237,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":9895,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1979,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The screening of a series of 11 metastatic breast tumors for the presence of the placental isoenzyme of alkaline phosphatase (EC 3.1.3.1) by RIA revealed one strong producer. The alkaline phosphatase of this tumor was characterized with respect to its immunochemical cross\u2010reactivity, inhibition by L\u2010phenylalanine and levamisole, subunit molecular weight (Mr) and isoelectric point (pl) in two\u2010dimensional electrophoresis, and one\u2010dimensional peptide map. In all parameters of the characterization, the tumor alkaline phosphatase was similar to placental alkaline phosphatase, except for subunit molecular weight which was slightly lower (60,000 versus 64,000 for the placental isoenzyme). No strong placental alkaline phosphatase producers were found among 16 primary tumors examined by RIA. The screening of patients' sera for the placental alkaline phosphatase using RIA indicated elevated levels over post\u2010menopausal controls in 20% of the metastatic patients. Only 3% of the primary patients had elevated serum levels. These results suggest that the placental isoenzyme of alkaline phosphatase may be a useful tumor marker for recurrent breast cancer.<\/jats:p>","DOI":"10.1002\/ijc.2910230608","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:45:55Z","timestamp":1171907155000},"page":"781-787","source":"Crossref","is-referenced-by-count":32,"title":["Demonstration of placental alkaline phosphatase in human breast cancer"],"prefix":"10.1002","volume":"23","author":[{"given":"H. 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Immunochemical identification of organ\u2010specific isoenzymes","volume":"243","author":"Sussman H. H.","year":"1968","journal-title":"J. biol. Chem."},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/clinchem\/22.7.972","article-title":"Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans","volume":"22","author":"Van Belle H.","year":"1976","journal-title":"Clin. 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