{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:33:00Z","timestamp":1699835580483},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":9865,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1979,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A high incidence of mammary tumors is found in multiparous GR mice during the 2nd and 3rd pregnancies and in nulliparous GR mice treated with estrone\/progesterone. The purpose of this study was to determine if prolactin is a contributing hormone in the genesis of these neoplasms. In one series of experiments, 238 15\u2010week\u2010old nulliparous GR mice were treated with estrone (drinking water, 0.5 mg\/liter) plus progesterone (30 mg progesterone pellet with cholesterol, implanted SC once monthly) for a period of 13 weeks. Half of these mice were injected SC once daily with 100 \u03bcg of the prolactin\u2010suppressing drug 2\u2010bromo\u2010\u03b1\u2010ergocryptine (CB\u2010154) for the duration of hormone treatment, and the other half were injected SC once daily with 0.9% NaCl solution (controls). In another series of experiments, 87 pregnant GR mice were divided into two groups and injected SC once daily from day 7 to 21 of pregnancy with 0.9% NaCl solution (controls) or CB\u2010154 (100 \u03bcg\/mouse). In the first series, the numbers of mice with mammary tumors and total number of mammary tumors were: controls, 58\/119 (49%) and 73; CB\u2010154 treatment, 34\/119 (29%) and 37, respectively. In the second series, the numbers were: controls, 39\/44 (89%) and 73; CB\u2010154 treatment, 24\/43 (56%) and 43, respectively. In both studies, CB\u2010154 treatment significantly (p&lt;0.05\u20130.005) reduced the percentage of mice with mammary tumors and total number of mammary tumors. These results provide evidence that prolactin is a contributing hormone in the genesis of estrone\/progesterone and pregnancy\u2010induced mammary tumors in female GR mice.<\/jats:p>","DOI":"10.1002\/ijc.2910240116","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:45:07Z","timestamp":1171907107000},"page":"92-96","source":"Crossref","is-referenced-by-count":9,"title":["Inhibition of mammary tumorigenesis in GR mice with 2\u2010bromo\u2010\u03b1\u2010ergocryptine"],"prefix":"10.1002","volume":"24","author":[{"given":"Clifford W.","family":"Welsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Goodrich\u2010Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn K.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/jnci\/57.3.527","article-title":"Hormone\u2010dependent mammary tumors in strain GR\/A mice. III. Effectiveness of supplementary hormone treatments in inducing tumorous phase growth","volume":"57","author":"Aidells B. D.","year":"1976","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-86-3-506"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910050202"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.123"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-146-38207"},{"key":"e_1_2_1_7_1","first-page":"13","article-title":"Suppression of the development of carcinogen\u2010induced mammary dysplasias in female Lewis rats by early chronic suppression of prolactin secretion","volume":"21","author":"Brown C. K.","year":"1978","journal-title":"Physiologist"},{"key":"e_1_2_1_8_1","first-page":"38","volume-title":"Physiopathology of cancer","author":"Dunn T. B.","year":"1959"},{"key":"e_1_2_1_9_1","first-page":"162","volume-title":"Prolactin and carcinogenesis","author":"Fl\u00fcckiger E.","year":"1972"},{"key":"e_1_2_1_10_1","first-page":"457","volume-title":"Neoplastic development","author":"Foulds L.","year":"1975"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-149-38800"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01931886"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5768.228"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.28.030166.000421"},{"key":"e_1_2_1_15_1","unstructured":"M\u00fchlbock O. The influence of hormones on spontaneous experimental tumours. In: Simposia sugli antimitotici pp.41\u201353 Lega Italiana per la Lotta Contro i Tumori San Remo (1955)."},{"key":"e_1_2_1_16_1","first-page":"75","article-title":"The transmission of the mammary tumor viruses","volume":"6","author":"M\u00fchlbock O.","year":"1968","journal-title":"Perspect Virol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-94-1-112"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(73)90008-X"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.180.4089.968"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/jnci\/52.1.189","article-title":"Effects of ergot drugs on prolactin and growth hormone secretion and on mammary nucleic acid content in C3H\/Bi mice","volume":"52","author":"Sinha Y. N.","year":"1974","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_21_1","first-page":"3253","article-title":"Estrogen receptor content and hormone responsive growth of mouse mammary tumors","volume":"34","author":"Sluyser M.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_22_1","first-page":"885","article-title":"Biological and morphological characteristics of mammary tumors in GR mice","volume":"46","author":"van Nie R.","year":"1971","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_23_1","first-page":"4054","article-title":"Prolactin and the development and progression of early neoplastic mammary gland lesions","volume":"38","author":"Welsch C. W.","year":"1978","journal-title":"Cancer Res."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.46"},{"key":"e_1_2_1_25_1","first-page":"2939","article-title":"Prophylaxis of spontaneously developing mammary carcinoma in C3H\/HeJ female mice by suppression of prolactin","volume":"33","author":"Welsch C. 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