{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:12:27Z","timestamp":1699834347647},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9772,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1979,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study was undertaken in order to evaluate the possibility of using anti\u2010tumor anti\u2010bodies as specific carriers of chemotherapeutic drugs to tumor metastases. Xenogeneic and syngeneic antisera were prepared against a metastasizing C57BL tumor, the Lewis lung carcinoma (3LL). The binding of absorbed xenogeneic and syngeneic anti\u20103LL sera or their Ig fractions to 3LL tumor cells was assayed by direct and indirect methods. Antisera prepared against tumor cells from a local growth reacted to a similar extent with cells obtained from the local tumor and with those obtained from the lung metastases. Radioiodinated immunoglobulins from syngeneic antisera injected into mice bearing metastases localized preferentially in metastasis\u2010bearing lungs as compared to several other organs tested. No such preferential uptake was observed either in mice bearing metastases injected with iodinated normal Ig or in normal mice injected with iodinated anti\u20103LL Ig. This relative accumulation in the metastasis\u2010bearing lungs was observed 3\u20134 days after the inoculation, when the whole Ig fraction was used, whereas a specific antibody\u2010enriched preparation localized as early as 24 h after injection. Daunomycin\u2014anti\u20103LL\u2010Ig conjugates were effective inhibitors of tumor cells from both local and the metastatic growths. They were more active than either the free drug or drug conjugates of normal Ig, in <jats:italic>in vitro<\/jats:italic> assays.<\/jats:p>","DOI":"10.1002\/ijc.2910240414","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:42:09Z","timestamp":1171906929000},"page":"461-470","source":"Crossref","is-referenced-by-count":12,"title":["Binding of anti\u2010tumor immunoglobulins and their daunomycin conjugates to the tumor and its metastases. <i>In vitro<\/i> and <i>in vivo<\/i> studies with lewis lung carcinoma"],"prefix":"10.1002","volume":"24","author":[{"given":"Esther","family":"Hurwitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilha","family":"Schechter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Arnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"270","volume-title":"Immunology of Cancer. 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