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The total age\u2010adjusted incidence rates were similar for these two countries, despite geographic and demographic differences. However, the most rapid changes in melanoma incidence were observed in females from Denmark and males from Connecticut. In addition, the largest increases occurred for lower\u2010extremity lesions in Danish middle\u2010aged women and trunk\u2010neck melanomas in Connecticut middle\u2010aged men. Melanoma of the face was resistant to changing incidence and occurred in an older age group than melanoma of other skin sites. In general, birth cohort analysis confirmed that changing incidence began for persons born around 1900, but the rising incidence for lower\u2010extremity melanomas in women and trunk\u2010neck melanomas in males began earlier. In comparing incidence for anatomic sites by correcting for surface area and melanocyte density, higher than expected rates were seen for melanoma of the face in both sexes and trunk\u2010neck melanomas in males. The data presented support the concept that a cumulative exposure to solar radiation may be important in the etiology of melanoma of the face, but short, intense sun exposure is probably related to melanoma in other sun\u2010exposed areas, and that melanoma in areas other than the face is responsible for the rising incidence of this disease.<\/jats:p>","DOI":"10.1002\/ijc.2910250113","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:30:37Z","timestamp":1171906237000},"page":"95-104","source":"Crossref","is-referenced-by-count":73,"title":["Malignant melanoma in Connecticut and Denmark"],"prefix":"10.1002","volume":"25","author":[{"given":"Alan","family":"Houghton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Flannery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Viola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197807)42:1<299::AID-CNCR2820420145>3.0.CO;2-8"},{"key":"e_1_2_1_3_1","first-page":"148","volume-title":"End results in cancer, Report No. 4. 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