{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:53:21Z","timestamp":1782147201872,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9680,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1980,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The subsets of small lymphocytes (surface lgm\u2010positive or B, Thy\u2010I\u2010positive or T and \u00abdouble\u2010negative\u00bb or null) appearing within spontaneous mammary tumors of C3H retired breeder female mice and in various lymphoid organs of the host at different stages of tumor development were characterized directly using a radioautographic method. Tumor\u2010bearing mice showed early transient splenomegaly and progressive atrophy of the thymus. The proportion of T small lymphocytes increased with tumor age within the tumor and in the spleen, blood and thymus; then, except in the spleen, these proportions declined again by 8 weeks of tumor growth. The incidence of B small lymphocytes showed no change in the tumor or thymus; there was an increase in the blood after 3 weeks, and a small decrease in the spleen after 7 weeks. At all the sites examined, the proportion of null small lymphocytes declined from an initial high level observed in the elderly tumor\u2010free control mice, and then recovered to control levels after 7 weeks. The absolute numbers of T and null cells in the spleen changed in parallel to their proportions, while splenic B\u2010cell numbers increased at 1\u20133 weeks. In the thymus the absolute numbers of all subsets decreased, with a late recovery of null cell numbers. Age\u2010matched control mice showed higher proportions of null cells in the spleen, blood and thymus, and lower proportions of T cells in the blood and spleen, than did young normal mice. This spontaneous tumor appears to be characterized by an increase in T cells, rather than in null cells, as observed for rapidly growing transplanted tumors. The null cell rise in the present case takes place before the clinical appearance of tumors. In both cases, however, tumor\u2010infiltrating B cells exhibited low levels of surface Ig, possibly related to a low level of maturation. The functional significance of these findings remains to be determined.<\/jats:p>","DOI":"10.1002\/ijc.2910250122","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:30:37Z","timestamp":1171906237000},"page":"159-168","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of lymphocyte subsets in spontaneous mouse mammary tumors and host lymphoid organs"],"prefix":"10.1002","volume":"25","author":[{"given":"V.","family":"Santer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Mastromarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. K.","family":"Lala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.4049\/jimmunol.118.6.2243","article-title":"Characterization and specificity of murine anti\u2010tumor cytotoxic effector cells within an ascitic tumor","volume":"118","author":"Biddison W. E.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_3_1","first-page":"1877","article-title":"In situ lymphoid cells of mouse mammary tumors. I. Development and evaluation of a method for the separation of lymphoid cells from mouse mammary tumors","volume":"120","author":"Blazar B.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.4049\/jimmunol.120.6.1881","article-title":"In situ lymphoid cells of mouse mammary tumors. II. The characterization of lymphoid cells separated from mouse mammary tumors","volume":"120","author":"Blazar B.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_5_1","first-page":"1887","article-title":"In sitiu lymphoid cells of mouse mammary tumors. III. In vitro stimulation of tumor cell survival by lymphoid cells separated from mammary tumors","volume":"120","author":"Blazar B. A.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(75)90163-X"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(74)90240-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910160615"},{"key":"e_1_2_1_9_1","first-page":"487","article-title":"Surface markers of small lymphocytes appearing in the mouse Ehrlich ascites tumour, host spleen and blood","volume":"34","author":"Garnis S.","year":"1978","journal-title":"Immunology"},{"key":"e_1_2_1_10_1","first-page":"564","article-title":"Inflammatory cells in solid murine neoplasms. IV. Cytolytic T lymphocytes isolated from regressing or progressing Moloney sarcomas","volume":"119","author":"Gillespie G. Y.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910210116"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0890114"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200316"},{"key":"e_1_2_1_14_1","first-page":"387","article-title":"Host responses within solid tumors. I. Monocytic effector cells within rat sarcomas","volume":"54","author":"Haskill J. S.","year":"1975","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910160512"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/jnci\/54.6.1323","article-title":"Immunologic, virologic, and genetic aspects of mammary tumor virus\u2010induced cell\u2010surface antigens: presence of these antigens and the Thy 1.2 antigen on murine mammary gland and tumor cells","volume":"54","author":"Hilgers J.","year":"1975","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4049\/jimmunol.117.2.440","article-title":"Two functionally distinct anti\u2010tumor effector cells isolated from primary murine sarcoma virus\u2010induced tumors","volume":"117","author":"Holden H. T.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_18_1","first-page":"279","article-title":"Post mitotic age of mononuclear cells migrating into TA\u20103 (St) solid tumors","volume":"10","author":"Kaizer L.","year":"1977","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910150607"},{"key":"e_1_2_1_20_1","first-page":"2247","article-title":"The stimulatory effect of tumor bearing upon the T and B\u2010cell subpopulations of the mouse spleen","volume":"33","author":"Konda S.","year":"1973","journal-title":"Cancer Res."},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/jnci\/60.6.1391","article-title":"In situ Fc\u2010receptor\u2010bearing cells in two murine tumors. II. Role in tumor immunity","volume":"60","author":"Korn J. H.","year":"1978","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_22_1","first-page":"293","article-title":"Dynamics of leukocyte migration into the mouse ascites tumor","volume":"7","author":"Lala P. K.","year":"1974","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_23_1","first-page":"1781","article-title":"Effects of tumor bearing on the dynamics of host hemopoietic cells","volume":"60","author":"Lala P. K.","year":"1976","journal-title":"Cancer Treat. Rep."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9101-6_127"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/jnci\/59.1.237","article-title":"Surface markers of small lymphocytes appearing in murina TA\u20103(St) solid tumors, host spleen and blood","volume":"59","author":"Lala P. K.","year":"1977","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.56.6.1735"},{"key":"e_1_2_1_27_1","first-page":"283","article-title":"Hemopoietic redistribution in tumor\u2010bearing mice","volume":"6","author":"Lala P. K.","year":"1978","journal-title":"Exp. Hemat."},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4049\/jimmunol.114.1_Part_1.24","article-title":"Characterization of cytotoxic effector cells in the mouse mammary tumor system","volume":"114","author":"Lane M. A.","year":"1975","journal-title":"J. Immunol."},{"key":"e_1_2_1_29_1","first-page":"2204","article-title":"The \u03b8 antigenicity of lymphoid organs of mice bearing the Ehrlich ascites tumor","volume":"30","author":"Loring M.","year":"1970","journal-title":"Cancer Res."},{"key":"e_1_2_1_30_1","first-page":"171","article-title":"Immunologic activity of the aged","volume":"3","author":"Makinodan T.","year":"1971","journal-title":"Advanc. Geront. Res."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(74)90232-9"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/jnci\/57.5.1157","article-title":"An assessment of intratumor phagocytic and surface marker\u2010bearing cells in a series of autochthonous and early passaged chemically induced murine sarcomus","volume":"57","author":"Pross H. F.","year":"1976","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170113"},{"key":"e_1_2_1_34_1","unstructured":"Richardson D. M. Spontaneous mammary tumor incidence in C3H\/HeJ mice. JAX Notes No. 413 (1973)."},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910180310"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910210313"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910160519"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1974.233"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200612"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(78)90306-7"},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4049\/jimmunol.120.1.286","article-title":"Immunologic responses to a murine mammary adenocarcinoma: in vitro production of specific killer cells is dependent on active T lymphocytes","volume":"120","author":"Yamamura Y.","year":"1978","journal-title":"J. Immunol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910250122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910250122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T12:55:29Z","timestamp":1699793729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910250122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1,15]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1,15]]}},"alternative-id":["10.1002\/ijc.2910250122"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910250122","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1,15]]}}}