{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:58Z","timestamp":1760188858077},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9649,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1980,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some human ovarian malignancies respond favorably to hormone therapy. In order to obtain more information about the endocrine properties of these malignancies, we measured estrogen (ER) and progestin (PR) receptors in 21 malignant ovarian tumors, and compared the findings with those in 29 benign tumors and 28 tumor\u2010like ovarian lesions. There were marked differences in steroid receptor distributions between the three groups. Only 38% of the malignant tumors simultaneously contained measurable amounts of both receptors, whereas the corresponding figure was 76% for the benign tumors. Malignant tumors were more often (29%) receptor\u2010negative than the benign ones (7%). The major difference in the tumor\u2010like lesions was the high frequency (43%) of samples containing PR only, as compared with the two other groups. The respective concentrations (fmol\/mg cytosol protein, mean \u00b1 SEM) of ER and PR were 114 \u00b1 42 and 148 \u00b1 76 (malignant tumors), 71 \u00b1 34 and 132 \u00b1 32 (benign tumors) and 19 \u00b1 16 and 251 \u00b1 88 (tumor\u2010like lesions). Of the malignant tumors, endometrioid carcinoma was characterized by a relatively high mean PR content (330 \u00b1 262), whereas in undifferentiated carcinoma a high ER content (149 \u00b1 97) was associated with a low PR concentration (26 \u00b1 15). Steroid receptor content was very similar in benign epithelial tumors with different histological properties. The two main groups of tumor\u2010like lesions, endometriosis and luteal cysts, typically contained little or no ER and a relatively high amount of PR. Hormone dependency of malignant and benign ovarian tumors and tumor\u2010like lesions does not seem similar. These data support the notion that receptor determinations from malignant ovarian tumors could aid in selection of patients for endocrine therapy in a manner similar to that already established for certain other hormone\u2010dependent cancers.<\/jats:p>","DOI":"10.1002\/ijc.2910250202","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:08:39Z","timestamp":1171908519000},"page":"175-179","source":"Crossref","is-referenced-by-count":57,"title":["Comparison of cytosol estrogen and progestin receptor status in malignant and benign tumors and tumor\u2010like lesions of human ovary"],"prefix":"10.1002","volume":"25","author":[{"given":"O.","family":"J\u00e1nne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kauppila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Syrj\u00e1l\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vihko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60974-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(79)90041-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1056\/NEJM197606102942405","article-title":"Mechanism of action of the sex steroid hormones","volume":"294","author":"Chan L.","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-526301-6.50016-1"},{"key":"e_1_2_1_6_1","first-page":"4340","article-title":"Human renal cell carcinoma as a hormone\u2010dependent tumor","volume":"38","author":"Concolino G.","year":"1978","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_1","first-page":"258","volume-title":"Endometrial cancer","author":"Ehrlich C. E.","year":"1978"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347809154895"},{"key":"e_1_2_1_9_1","first-page":"4345","article-title":"Correlation between clinical response to hormone therapy and steroid receptor content in prostatic cancer","volume":"38","author":"Gustafsson J.\u2010\u00c5.","year":"1978","journal-title":"Cancer Res."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1979.tb10799.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1971.tb01256.x"},{"key":"e_1_2_1_12_1","first-page":"50","article-title":"Estrogen and progestin binding in cytosols of ovarian adenocarcinomas","volume":"53","author":"Holt J. A.","year":"1979","journal-title":"Obstet. Gynec."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910240505"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(75)90179-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(76)90034-0"},{"key":"e_1_2_1_16_1","first-page":"225","article-title":"Progesterone receptors and regulation of progestin action in mammalian tissues","volume":"56","author":"J\u00e5nne O.","year":"1978","journal-title":"Med. Biol."},{"key":"e_1_2_1_17_1","first-page":"214","article-title":"Steroid binding properties of estradiol receptors in human breast cancer","volume":"53","author":"J\u00e5nne O.","year":"1975","journal-title":"Med. Biol."},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","unstructured":"Kauppila A. J\u00e5nne O. Kujansuu E. andVihko R. Treatment of advanced endometrial adenocarcinoma with a combined cytotoxic therapy: predictive value of cytosol estrogen and progestin receptor levels.Cancer in press (1980).","DOI":"10.1002\/1097-0142(19801115)46:10<2162::AID-CNCR2820461010>3.0.CO;2-V"},{"key":"e_1_2_1_19_1","volume-title":"Steroid cell interactions","author":"King R. J. B.","year":"1974"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(73)90340-1"},{"key":"e_1_2_1_21_1","first-page":"574","article-title":"Progesterone\u2010binding proteins: in vitro binding and biological activity of different steroid ligands","volume":"78","author":"Kontula K.","year":"1975","journal-title":"Acta endocr."},{"key":"e_1_2_1_22_1","first-page":"230","volume-title":"Annual report on the results of treatment in carcinoma of the uterus, vagina and ovary","author":"Kottmeier H.\u2010L.","year":"1978"},{"key":"e_1_2_1_23_1","first-page":"719","article-title":"Etiology of cancer of the human ovary: A review","volume":"22","author":"Lingeman C. H.","year":"1974","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107353"},{"key":"e_1_2_1_25_1","first-page":"4251","article-title":"Clinical implications of glucocorticoid receptors in human leukemia","volume":"38","author":"Lippman M. E.","year":"1978","journal-title":"Cancer Res."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_27_1","first-page":"283","volume-title":"Gynecologic oncology","author":"McGowan L.","year":"1978"},{"key":"e_1_2_1_28_1","volume-title":"Progress in cancer research and therapy. Vol. 10, Hormones, receptors and breast cancer","author":"McGuire W. L.","year":"1978"},{"key":"e_1_2_1_29_1","volume-title":"Estrogen receptors and human breast cancer","author":"McGuire W. L.","year":"1975"},{"key":"e_1_2_1_30_1","first-page":"148","article-title":"A case control study of carcinoma of the ovary","volume":"31","author":"Newhouse M. L.","year":"1977","journal-title":"Brit. J. prevent. soc. Med."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(76)90042-3"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(75)90088-6"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1949.tb27297.x"},{"key":"e_1_2_1_34_1","volume-title":"International histological classification of tumors. No. 9","author":"Serov S. F.","year":"1973"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.49.568.77"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197604152941605"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910250202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910250202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:39:03Z","timestamp":1699803543000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910250202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2,15]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,2,15]]}},"alternative-id":["10.1002\/ijc.2910250202"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910250202","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,2,15]]}}}