{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:51:41Z","timestamp":1759683101878},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":9590,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1980,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using a specific antiserum to human syncytial trophoblast plasma membrane (TrPM), we have investigated the expression of these antigens on a variety of trophoblastic and non\u2010trophoblastic tissues by a standard peroxidase\/anti\u2010peroxidase staining method. Normal placenta (first\u2010trimester as well as full\u2010term), placenta from tubal pregnancy and placenta accreta were all found to express TrPM antigens. However, malignant change in trophoblast neoplasms appeared to be accompanied by a loss of these antigens, with 7 out of 10 specimens of hydatidiform mole staining positively while 3 specimens of invasive mole and 7 specimens of choriocarcinoma were all negative. In contrast, a number of malignant tumours of non\u2010trophoblastic origin such as carcinomas of the colon, cervix, bladder and hepatomas were found to express TrPM antigens. The possible significance of the reversal to a trophoblast phenotype by malignant neoplasms of non\u2010trophoblastic origin is discussed.<\/jats:p>","DOI":"10.1002\/ijc.2910250406","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:07:05Z","timestamp":1171908425000},"page":"459-461","source":"Crossref","is-referenced-by-count":24,"title":["Differential expression of trophoblast\u2010specific membrane antigens by normal and abnormal human placentae and by neoplasms of trophoblastic and non\u2010trophoblastic origin"],"prefix":"10.1002","volume":"25","author":[{"given":"Y. W.","family":"Loke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Whyte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"xxv","volume-title":"Onco\u2010developmental gene expression","author":"Fishman W. H.","year":"1976"},{"key":"e_1_2_1_3_1","first-page":"64","volume-title":"Pathology of the placenta","author":"Fox H.","year":"1978"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347509156749"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/259416a0"},{"key":"e_1_2_1_6_1","first-page":"20","volume-title":"Immunology and immunopathology of the human foetal\u2010maternal interaction","author":"Loke Y. W.","year":"1978"},{"key":"e_1_2_1_7_1","first-page":"3476","article-title":"Human chorionic gonadotropin in human neoplastic cells","volume":"36","author":"McManus L. M.","year":"1976","journal-title":"Cancer Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.867042"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/jnci\/50.3.669","article-title":"Production of human chorionic gonadotrophin in vitro by a cell line derived from a carcinoma of the lung","volume":"50","author":"Rabson A. S.","year":"1973","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910240103"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/18.5.315"},{"key":"e_1_2_1_12_1","first-page":"359","article-title":"Antigens of the human trophoblast plasma membrane","volume":"37","author":"Whyte A.","year":"1979","journal-title":"Clin. exp. Immunol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910250406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910250406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T13:31:11Z","timestamp":1699795871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910250406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,4,15]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,4,15]]}},"alternative-id":["10.1002\/ijc.2910250406"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910250406","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,4,15]]}}}