{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:33:53Z","timestamp":1699835633535},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9283,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1981,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with operable breast cancer were tested postoperatively to assess lymphoproliferative responses. Patients with lymphocytes capable of recognizing and proliferating in response to autologous tumor extracts had a significantly longer disease\u2010free interval than those with a low response to their autologous extract. In this group of patients, immunological responses to autologous tumors predicted subsequent clinical course better than pathological evaluation based on tumor presence in axillary lymph nodes. Low or negative reactivity to autologous tumor often was not accompanied by a general, impaired ability to respond in LP assays. In fact, patients with low autologous tumor response and normal MLC were at a particularly high risk for recurrence.<\/jats:p>","DOI":"10.1002\/ijc.2910270202","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:18:49Z","timestamp":1171909129000},"page":"131-138","source":"Crossref","is-referenced-by-count":17,"title":["Lymphoproliferative responses to autologous tumor extracts as prognostic indicators in patients with resected breast cancer"],"prefix":"10.1002","volume":"27","author":[{"given":"G. B.","family":"Cannon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Herberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Keels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Alford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197404)33:4<1145::AID-CNCR2820330438>3.0.CO;2-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90003-3"},{"key":"e_1_2_1_4_1","first-page":"98","volume-title":"Biological relevance of immune suppression","author":"Cannon G. B.","year":"1980"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910250103"},{"key":"e_1_2_1_6_1","first-page":"363","volume-title":"Compendium of assays for immunodiagnosis of human cancer","author":"Dean J. H.","year":"1979"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200307"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/jnci\/58.3.549","article-title":"Cell\u2010mediated immune response of breast cancer patients to autologous tumor\u2010associated antigens","volume":"58","author":"Dean J. H.","year":"1977","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910160314"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.4049\/jimmunol.115.5.1449","article-title":"Functional activities of rosette separated human peripheral blood leukocytes","volume":"115","author":"Dean J. H.","year":"1975","journal-title":"J. Immunol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.4049\/jimmunol.116.6.1507","article-title":"In vivo protection against syngeneic Gross virus\u2010induced lymphoma in rats: comparison with in vitro studies of cell\u2010mediated immunity","volume":"116","author":"Glaser M.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_12_1","first-page":"1001","article-title":"Role of suppressor cells in depression of in vitro lymphoproliferative responses of lung cancer and breast cancer patients","volume":"61","author":"Jerrells T. R.","year":"1978","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00258288"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/2031188a0"},{"key":"e_1_2_1_15_1","first-page":"45","article-title":"Delayed cutaneous hypersensitivity reactions to membrane extracts of human tumors","volume":"9","author":"Oren M. E.","year":"1971","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.4049\/jimmunol.118.5.1517","article-title":"Characteristics of the immature cells involved in T\u2010cell mediated enhancement of syngeneic tumor growth","volume":"118","author":"Small M.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_17_1","first-page":"998","volume-title":"Immunodiagnosis of cancer","author":"V\u00e1nky F. T.","year":"1979"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910270202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910270202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:28:46Z","timestamp":1699802926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910270202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,2,15]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,2,15]]}},"alternative-id":["10.1002\/ijc.2910270202"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910270202","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,2,15]]}}}