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In all sarcomas the individual tumor cells were surrounded by a network of fibronectin which was continuous with the stroma. The distribution of fibronectin was similar in the benign soft\u2010tissue tumors. In contrast, no fibronectin was detected in the individual carcinoma cells or in their periphery. However, the reactive connective tissue stroma of carcinomas was strongly positive for fibronectin. This was true also for the stroma of benign epithelial tumors. These results show that, contrary to the situation in cell culture,<jats:italic>in vivo<\/jats:italic>sarcoma cells and benign soft\u2010tissue tumor cells contain fibronectin in their pericellular matrix. On the other hand, fibronectin can be used to distinguish carcinomas from sarcomas<jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910270403","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:15:03Z","timestamp":1171908903000},"page":"427-435","source":"Crossref","is-referenced-by-count":100,"title":["Fibronectin in human solid tumors"],"prefix":"10.1002","volume":"27","author":[{"given":"Svante","family":"Stenman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Vaheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90096-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109185"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.10.3570"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jss.400120111"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418575"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90050-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910260410"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910240416"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.6.1779"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.82.1.1"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(79)90313-0"},{"key":"e_1_2_1_13_1","first-page":"47","article-title":"Sequential appearance of fibronectin and collagen in experimental granulation tissue","volume":"43","author":"Kurkinen M.","year":"1980","journal-title":"Lab. 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