{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:48:39Z","timestamp":1770720519702,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9133,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1981,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of tumor growth on the suppressor cell activity of melanoma patients was examined by measurement of immunoglobulin produced <jats:italic>in vitro<\/jats:italic> in pokeweed mitogen (PWM)\u2010stimulated cultures of B and T lymphocytes. B and T cells were separated by sheep red blood cell resetting and suppressor cell activity was assessed by comparison of immunoglobulins produced in cultures with irradiated T cells (2,000 rads) to that with unirradiated T cells. In the majority of patients with localized melanoma, radiosensitive suppressor T cells were detected and appeared to be an augmentation of a normal physiological state. In patients with Stage I and II melanoma, removal of the tumor resulted in a significant decrease in suppressor activity against IgA and IgM but not against IgG production. Similar sequential changes in suppressor cell activity were not generally detected in patients who had surgery for skin graft after previous removal of the primary melanoma or in patients undergoing surgery for non\u2010malignant conditions. Sequential studies on the levels of serum immunoglobulins showed an apparent trend for immunoglobulins to increase after surgery. Of particular importance, the decrease in <jats:italic>in vitro<\/jats:italic> suppressor cell activity against IgM and IgG production after tumor removal in individual patients was significantly associated with an increase in immunoglobulin levels in the serum of these patients. It is suggested that these findings may account in part for the absence of detectable antibody responses to melanoma antigens in many patients and for the generalized immunodeficiency in patients with disseminated melanoma.<\/jats:p>","DOI":"10.1002\/ijc.2910280102","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:12:24Z","timestamp":1171908744000},"page":"1-9","source":"Crossref","is-referenced-by-count":22,"title":["Suppressor cell activity in melanoma patients. I. Relation to tumor growth and immunoglobulin levels <i>in vivo<\/i>"],"prefix":"10.1002","volume":"28","author":[{"given":"J.","family":"Werkmeister","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hersey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"21","author":"Boyum A.","year":"1968","journal-title":"Scand. J. clin. lab. Invest."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197510302931801"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197812142992404"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.10.4052"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.4049\/jimmunol.116.3.791","article-title":"Regulation of the immune responses to tumor antigens. I. Immunosuppressor cells in tumor\u2010bearing hosts","volume":"116","author":"Fujimoto S.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197711032971802"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800415)45:8<2102::AID-CNCR2820450818>3.0.CO;2-I"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60311-9"},{"key":"e_1_2_1_10_1","first-page":"104","article-title":"Characterization of mononuclear effector cells in human blood","volume":"23","author":"Hersey P.","year":"1976","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910250204"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(78)90296-7"},{"key":"e_1_2_1_13_1","first-page":"698","article-title":"Hypogammaglobulinaemia associated with abnormalities of both B and T lymphocytes in patients with chronic lymphatic leukaemia","volume":"39","author":"Hersey P.","year":"1980","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_14_1","first-page":"3134","article-title":"Radiosensitive, thymic hormone\u2010sensitive peripheral blood suppressor cell activity in cancer patients","volume":"40","author":"Hersh E. M.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6081.218"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(74)90003-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/257396a0"},{"key":"e_1_2_1_18_1","first-page":"371","article-title":"Suppressor cells in tumour bearing mice and rats","volume":"24","author":"Kirchner H.","year":"1976","journal-title":"Biomedicine"},{"key":"e_1_2_1_19_1","first-page":"563","article-title":"BCG\u2010induced suppressor cells. I. Demonstration of a macrophage\u2010like suppressor cell that inhibits cytotoxic T\u2010cell generation in vitro","volume":"120","author":"Klimpel G. R.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.184"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910210507"},{"key":"e_1_2_1_22_1","first-page":"277","article-title":"Macrophages and resistance to tumors. I. Inhibition of delayed\u2010type hypersensitivity reactions by tumor cells and by soluble products affecting macrophages","volume":"34","author":"Nelson M.","year":"1978","journal-title":"Immunology"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.4049\/jimmunol.120.5.1573","article-title":"Melanoma\u2010associated immunosuppression through B cell activation of suppressor T cells","volume":"120","author":"Ninneman J. L.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.4049\/jimmunol.117.4.1243","article-title":"Depression of macrophage function by a factor produced by neoplasms. A mechanism for abrogation of immune surveillance","volume":"117","author":"Pike M. C.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197911223012101"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91940-0"},{"key":"e_1_2_1_27_1","first-page":"366","article-title":"The effect of irradiation of T\u2010cell suppression of ELISA\u2010determined Ig production by human blood B\u2010cells in vitro","volume":"38","author":"Wasserman J.","year":"1979","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_28_1","first-page":"487","article-title":"Characterization of an inhibitor of cell division released in tumour cell cultures","volume":"41","author":"Werkmeister J.","year":"1980","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_29_1","first-page":"168","article-title":"Detection of an inhibitor of cell division in cultures of tumour cells with immunosuppressive activity in vitro","volume":"40","author":"Werkmeister J.","year":"1980","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00200005"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","unstructured":"Werkmeister J. Phillips G. McCarthy W. andHersey P. Suppressor cell\u2010activity in melanoma patients. II. Concanavalin A\u2010induced suppressor cells in relation to tumour growth and suppressor T\u2010cell subsets.Int. J. Cancer submitted (1981).","DOI":"10.1002\/ijc.2910280103"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/55.3.283"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707212970301"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910280102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910280102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:16:46Z","timestamp":1699787806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910280102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7,15]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,7,15]]}},"alternative-id":["10.1002\/ijc.2910280102"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910280102","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,7,15]]}}}