{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:07:11Z","timestamp":1699834031586},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9133,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1981,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relative proportions of T, B and T\u03b3 suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)\u2010induced suppression against lymphocyte mitogenesis of melanoma patients and age\u2010matched controls was measured concurrently. The mean percentage of T\u03b3 cells was significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.001) in melanoma patients before surgery (21.8 \u00b1 5.4) compared to a group of age\u2010matched controls (14.9 \u00b1 5.4). There was a tendency for the proportion of T\u03b3 cells in patients to decrease after surgery, although the relative levels of T\u03b3 were still significantly elevated (<jats:italic>p<\/jats:italic> &lt; 0.05) 6\u20138 weeks after surgery when compared to normal controls. The mean percentage of T and B cells in melanoma patients before and after surgery was comparable to that observed in normal controls. The degree of Con\u2010A\u2010induced suppression in patients increased significantly after surgery particularly at 6\u20138 weeks (<jats:italic>p<\/jats:italic> &lt; 0.02). No difference in Con\u2010A\u2010induced suppressor cell activity was observed between melanoma patients and controls before or after surgery. An inverse relationship was found between the amount of Con\u2010A\u2010induced suppression and percentage of T\u03b3 cells in melanoma patients before surgery. Similar associations were not apparent in patients after surgery or in normal control populations. The inverse correlation of Con\u2010A\u2010induced suppression with T\u03b3 cell numbers suggests that the former may measure potential suppressor cell activity whereas the T\u03b3 cells may indicate active suppressor cells. The significance of these findings for the monitoring of suppressor cell activity <jats:italic>in vivo<\/jats:italic> and their role in suppression of immune responses in melanoma patients is discussed.<\/jats:p>","DOI":"10.1002\/ijc.2910280103","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:12:24Z","timestamp":1171908744000},"page":"11-15","source":"Crossref","is-referenced-by-count":11,"title":["Suppressor cell activity in melanoma patients. II. 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