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The early phase defect was observed 2\u20135 days and 4\u201312 days after tumor transplantation in rats and mice respectively. Although transient, its duration could be prolonged by increasing the number of tumor cells injected. An interval of normal responses separated this early defect from a second or late\u2010phase defect which began midway in the clinical course and persisted until death. Transplantation of syngeneic liver cells increased macrophage responses in DA rats but had no effect in SJL\/J mice. The demonstration of a bisphasic anti\u2010inflammatory effect following tumor transplantation suggests that low doses of tumor cells are effective in inhibiting macrophages and that tumor bearing may alter macrophage responses by more than one mechanism.<\/jats:p>","DOI":"10.1002\/ijc.2910280212","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:10:46Z","timestamp":1171908646000},"page":"185-190","source":"Crossref","is-referenced-by-count":13,"title":["Biphasic depression of macrophage function after tumor transplantation"],"prefix":"10.1002","volume":"28","author":[{"given":"Sigurd J.","family":"Normann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Sorkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1341","article-title":"Do macrophages destroy nascent tumors?","volume":"62","author":"Adams D. 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