{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:06:37Z","timestamp":1699833997676},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":8919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1982,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The T\u2010cell enzyme markers, terminal deoxy\u2010nucleotidyl transferase (TdT) and 20 \u03b1 hydroxysteroid dehydrogenase (20 \u03b1 SDH), were used to classify lymphomas induced by the Moloney leukemia virus (M\u2010MuLV). Different subtypes of T cells were shown to be involved in different types of lymphoma. Thymomas were TdT\u2010positive and grew as subcutaneous solid tumors at the site of inoculation. Spleen cells from mice with generalized lymphoma were of two types. In the majority of cases the lymphomas consisted of 20 \u03b1 SDH\u2010positive cells that homed to spleen and lymph nodes upon transplantation. In a few cases the cells of enlarged spleens were TdT\u2010positive and, like the TdT\u2010positive thymomas, could be transplanted as subcutaneous tumors. Thus, TdT\u2010positive and 20 \u03b1 SDH\u2010positive T\u2010cell lymphomas can be distinguished by their homing properties. Preleukemic thymus cells from M\u2010MuLV inoculated mice can, after transfer to 400\u2010R irradiated syngeneic hosts, induce new lymphomas by virus release or grow in an autonomous fashion in the recipients. Whether of donor or recipient type, these lymphomas are TdT\u2010positive. In contrast, preleukemic bone marrow cells give lymphomas of donor type which are as heterogeneous for T\u2010cell enzymes as are lymphomas induced by neonatal inoculation of M\u2010MuLV.<\/jats:p>","DOI":"10.1002\/ijc.2910290209","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:45:35Z","timestamp":1171910735000},"page":"163-167","source":"Crossref","is-referenced-by-count":7,"title":["Different t\u2010cell subtypes are associated with pathologically distinct forms of moloney leukemia virus (m\u2010mulv)\u2010induced lymphoma"],"prefix":"10.1002","volume":"29","author":[{"given":"Birgitta","family":"\u00c5sj\u00f6","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Maria","family":"Fenyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambert","family":"Skoog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(81)90035-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(80)90049-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_1_5_1","unstructured":"Feny\u00f6 E. M. \u00c5sj\u00f6 B. andSpira J. Surface antigens on Moloney leukemia cells: lack of correlation with clinical form and karyotype.In:Advances in comparative leukemia research in press (1981)."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.4049\/jimmunol.123.3.1266","article-title":"20 \u03b1 hydroxysteroid dehydrogenase activity in New Zealand mice. T lymphocytes and bone marrow cells: effect of age, sex and castration","volume":"123","author":"Fuks A. S.","year":"1979","journal-title":"J. Immunol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910210513"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.141.4.855","article-title":"Murine terminal deoxynukleotidyl transferase: cellular distribution and response to cortisone","volume":"141","author":"Kuno P. C.","year":"1975","journal-title":"J. exp. 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