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Sera of patients with BL and NPC as well as sera of patients with other malignant and non\u2010malignant diseases were tested for antibodies against gp40, using a double antibody radioimmunoassay. Practically all normal sera and sera of patients with non\u2010malignant diseases had antibodies capable of binding radioiodinated gp40. In contrast, sera of patients with BL or NPC had very low binding, while sera of patients with other malignant diseases had intermediate binding values. The low binding activity of BL\/NPC sera was shown to be due to inhibition by excess gp40 present in such sera. Effusions of patients with breast or ovarian cancer also contained demonstrable amounts of gp40. The origin of gp40 is still unknown.<\/jats:p>","DOI":"10.1002\/ijc.2910290608","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:41:16Z","timestamp":1171910476000},"page":"645-651","source":"Crossref","is-referenced-by-count":5,"title":["Reactivity with patient antibodies of partially purified gp40 antigen from immune complexes in burkitt's lymphoma and nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"29","author":[{"given":"Y.","family":"Gazitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sultzeanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(69)90178-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.5.2420"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(81)90035-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(81)74046-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910180307"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1978.tb00459.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910060316"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910080316"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.115.6.1617","article-title":"Rapid isolation of antigens from cells with a staphylococcal protein A \u2010 antibody absorbent: Parameters of the interaction of antibody\u2010antigen complexes with protein A","volume":"115","author":"Kessler S. 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