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In the case of the DDf strain the tumors are adenoacanthomas, but in the case of the other strains adenocarcinomas are also observed. The effect of urethane in the drinking water on expression of endogenous retroviral structural proteins of the B and C type (MTV and MuLV) was studied in the milk by an immunodiffusion test and in organ extracts by radioimmunoassays (for MTVp27, MTVgp52 and MuLVp30). Organs tested include salivary glands, thymus and spleen from female and male animals. In addition, prostate and seminal vesicles were tested in male animals and uterus and mammary glands in females. Mammary tumors induced by urethane were also tested. Urethane does not induce or enhance endogenous retroviral antigen expression, either in these organs or in the mammary gland, one of the target organs for tumorigenesis by this agent.<\/jats:p>","DOI":"10.1002\/ijc.2910300117","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:06:03Z","timestamp":1171911963000},"page":"101-106","source":"Crossref","is-referenced-by-count":1,"title":["Mammary tumor induction in inbred mouse strains with urethane is not accompanied by changes in expression of B\u2010 and C\u2010type retroviral structural proteins"],"prefix":"10.1002","volume":"30","author":[{"given":"Shunsuke","family":"Imai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Tsubura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Hilgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"309","volume-title":"RNA viruses and host genome in oncogenesis","author":"Bentvelzen P.","year":"1972"},{"key":"e_1_2_1_3_1","first-page":"311","volume-title":"Viral oncology","author":"Bentvelzen P.","year":"1980"},{"key":"e_1_2_1_4_1","first-page":"835","volume-title":"Lung tumors in animals","author":"Bentvelzen P.","year":"1966"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/jvi.38.2.571-580.1981","article-title":"Partial expression of endogenous mouse mammary tumor virus in mammary tumors induced in BALB\/c mice by chemical, hormonal, and physical agents","volume":"38","author":"Butel J. 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