{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:42:21Z","timestamp":1790048541417,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8706,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1982,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type\u2010C RNA tumor viruses have been implicated in the etiology of naturally occurring leukemias and lymphomas of animals. Human T\u2010cell leukemia\/lymphoma virus (HTLV) is the first human virus of this class consistently identified in association with a specific type of human leukemia\/lymphoma. The isolation of HTLV was made possible by the ability to grow mature T\u2010cells in tissue culture usually with T\u2010cell growth factor (TCGF). We now report a cluster of adult T\u2010cell leukemia\/lymphoma among Blacks from the Caribbean in which all eight cases are positive for HTLV virus and\/or antibody. These patients have disease that appears indistinguishable from Japanese adult T\u2010cell leukemia\/lymphoma which, as we have also reported, is associated with HTLV in over 90% of cases. The finding of HTLV antibodies in some of the normal population in the Caribbean and Japan, and the clustering of a specific form of T\u2010cell leukemia\/lymphoma in these virus\u2010endemic areas, suggest that HTLV infection may be associated with the occurrence of a distinctive clinico\u2010pathologic entity.<\/jats:p>","DOI":"10.1002\/ijc.2910300302","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:16:49Z","timestamp":1171912609000},"page":"257-264","source":"Crossref","is-referenced-by-count":420,"title":["The human type\u2010C retrovirus, HTLV, in blacks from the Caribbean region, and relationship to adult T\u2010cell leukemia\/lymphoma"],"prefix":"10.1002","volume":"30","author":[{"given":"William A.","family":"Blattner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. S.","family":"Kalyanaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Robert\u2010Guroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Andrew","family":"Lister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A. G.","family":"Galton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem S.","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin","family":"Greaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92200-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60973-2"},{"key":"e_1_2_1_4_1","first-page":"893","article-title":"Studies on the relationship between infection with bovine C\u2010type virus leukemia, and persistent lymphocytosis in cattle","volume":"34","author":"Ferrer J. F.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_1","unstructured":"Gallo R. C. Kalyanaraman V. S. Sarngadharan M. G. Sliski A. Vonderheid E. Maeda M. Nakao Y. Ito Y. Gutensohn N. Evans A. Murphy S. Bunn P. A. Catovsky D. Greaves M. Blattner W. A. Jarrett W. F. H. zur Hausen H. Seligmann M. Brouet J. C. Metzgar R. Haynes B. F. Jaffe E. Broder S. Fisher R. Cossman J. Golde D. andRobert\u2010Guroff M. Association of the human T\u2010cell retrovirus HTLV with a subset of adult T\u2010cell malignancies as evidenced by viral\u2010specific natural antibodies (Submitted for1982)."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","unstructured":"Gallo R. C. Mann D. L. Broder S. Ruscetti F. W. Maeda M. Kalyanaraman V. S. Robert\u2010Guroff M. andReitz M. S. Human T\u2010cell leukemia\/lymphoma virus (HTLV) in T\u2010 but not B\u2010lymphocytes from a patient with cutaneous T\u2010cell lymphoma.Proc. nat. Acad. Sci. (Wash.) in press (1982).","DOI":"10.1073\/pnas.79.18.5680"},{"key":"e_1_2_1_7_1","article-title":"Regulation of human T\u2010cell proliferation: T\u2010cell growth factor and isolation of a new class of type\u2010C retroviruses from human T\u2010cells","volume":"26","author":"Gallo R. C.","journal-title":"Hematology and blood transfusion"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/978-3-642-67984-1","volume-title":"Modern trends in human leukemia","author":"Neth R.","year":"1981"},{"key":"e_1_2_1_8_1","unstructured":"Gallo R. C. andReitz M. S. Jr. Human retroviruses and adult T\u2010cell leukemia\u2010lymphoma.J. nat. Cancer Inst. in press. (1982)."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_10_1","first-page":"453","article-title":"Genetic determinants of blood pressure level among the black Caribs of St. Vincent","volume":"533","author":"Hutchinson J.","year":"1981","journal-title":"Hum. Biol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/202566a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/294271a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.5.1653"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1128\/jvi.38.3.906-915.1981","article-title":"Immunological properties of a type\u2010C retrovirus isolated from cultured human T\u2010lymphoma cells and comparison to other mammalian retroviruses","volume":"38","author":"Kalyanaraman V. S.","year":"1981","journal-title":"J. Virol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.10.6134"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.181845"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.4.1291"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.11.6815"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/294268a0"},{"key":"e_1_2_1_22_1","unstructured":"Popovic M. Kalyanaraman V. S. Sarngadharan M. G. Robert\u2010Guroff M. Nakao Y. Reitz Jr. M. S. Miyoshi I. Ito Y. Minowada J. andGallo R. C. HTLV is the virus of Japanese adult T\u2010cell leukemia(submitted for1982)."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.2.333"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.3.1887"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(81)90642-5"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","unstructured":"Robert\u2010Guroff M. Fahey K. A. Maeda M. Nakao Y. Ito Y. andGallo R. C. Identification of HTLV\u2010p19 specific natural human antibodies by competition with monoclonal antibody.Virology in press (1982a).","DOI":"10.1016\/0042-6822(82)90229-X"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6760397"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.6.1957"},{"key":"e_1_2_1_29_1","first-page":"357","article-title":"Comparison of clinical, morphologic and immunologic characteristics of adult T\u2010cell leukemia\u2010lymphoma and cutaneous T\u2010cell lymphoma","volume":"9","author":"Shimoyama M.","year":"1979","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_30_1","first-page":"317","article-title":"Adult T\u2010cell leukemia: further clinical observations and cytogenetic and functional studies of leukemic cells","volume":"9","author":"Takatsuki K.","year":"1979","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_31_1","first-page":"15","article-title":"Statistical analysis of immunologic, clinical and histopathologic data on lymphoid malignancies in Japan","volume":"11","author":"The T\u2010 and B\u2010Cell Malignancy Study Group","year":"1981","journal-title":"Jap. J. clin. Oncol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910300302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910300302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:13:42Z","timestamp":1699802022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910300302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9,15]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,9,15]]}},"alternative-id":["10.1002\/ijc.2910300302"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910300302","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,9,15]]}}}