{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:56:01Z","timestamp":1771876561578,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8706,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1982,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic, pathologic, and immunologic studies were done on 10 patients with lymphoblastic lymphoma (LL). The median age was 21 years, and males predominated in a ratio of 9:1. At the time of diagnosis, 6 of the 10 patients had an anterior mediastinal mass, 3 had bone marrow involvement, and 2 had central nervous system involvement. All patients were treated with intensive combination chemotherapy. The median survival of the 8 patients who died (7 of whom were adults) was 10.5 months; all 8 achieved only a partial remission. Two other patients were children; they continue in complete remission. Immunologic marker studies were done on 9 of the patients; 5 had T\u2010cell LL, and the other 4 had non\u2010T, non\u2010B LL. In a study of T\u2010cell subpopulations with the use of monoclonal antibodies, the malignant T cells of the 2 patients tested appeared to be mature thymocytes. Clonal chromosome abnormalities were seen in involved tissues from 8 patients; the other 2 patients had a normal karyotype. A 9q+ chromosome, a 6q\u2010chromosome, and a 1q\u2010chromosome associated with 1q trisomy were each seen in 2 patients. No patient had a 14q+ chromosome, which is the most common abnormality in various lymphoproliferative disorders, including other T\u2010cell malignant diseases. The variable chromosome pattern in LL could be related to the heterogeneity of the immunologic phenotype of the malignant T cells. More data are needed before it can be established whether there are any correlations between a particular karyotype and the immunologic phenotype of LL cells.<\/jats:p>","DOI":"10.1002\/ijc.2910300304","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:16:49Z","timestamp":1171912609000},"page":"273-279","source":"Crossref","is-referenced-by-count":38,"title":["Lymphoblastic lymphoma: Cytogenetic, pathologic, and immunologic studies"],"prefix":"10.1002","volume":"30","author":[{"given":"Yasuhiko","family":"Kaneko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daina","family":"Variakojis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Kluskens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830060310"},{"key":"e_1_2_1_3_1","first-page":"147","volume-title":"Conflicts in childhood cancer: an evaluation of current management","author":"Barcos M. P.","year":"1975"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/blood.V57.6.1105.1105","article-title":"Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: Evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphoma","volume":"57","author":"Bernard A.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.3.526.526"},{"key":"e_1_2_1_6_1","first-page":"3119","article-title":"Chromosome abnormalities in poorly differentiated lymphocytic lymphoma","volume":"39","author":"Fukuhara S.","year":"1979","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.3.645.645"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130909"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-3-415"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1182\/blood.V48.2.213.213","article-title":"Heterogeneity of immunologic markers and surface morphology in childhood lymphoblastic lymphoma","volume":"48","author":"Jaffe E. S.","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_11_1","first-page":"2918","article-title":"Correlation of karyotype with clinical features in acute lymphoblastic leukemia (ALL)","volume":"42","author":"Kaneko Y.","year":"1982","journal-title":"Cancer Research"},{"key":"e_1_2_1_12_1","unstructured":"Kaneko Y. Variakojis D. andRowley J. D. in preparation."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1964.tb01953.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2127::AID-CNCR2820440625>3.0.CO;2-G"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90092-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197608)38:2<964::AID-CNCR2820380248>3.0.CO;2-V"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197709)40:3<1161::AID-CNCR2820400327>3.0.CO;2-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1588"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198008143030704"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-3-319"},{"key":"e_1_2_1_21_1","first-page":"255","article-title":"Chromosome studies in non\u2010Hodgkin's lymphomas","volume":"7","author":"Rowley J. D.","year":"1980","journal-title":"Semin. Oncol."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197602)37:2<790::AID-CNCR2820370227>3.0.CO;2-Q"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810515)47:10<2510::AID-CNCR2820471034>3.0.CO;2-8"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1182\/blood.V56.5.759.759","article-title":"Multimarker classification of acute lymphoblastic leukemia: evidence for further T subgroups and evaluation of their clinical significance","volume":"56","author":"Thiel E.","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90075-3"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1182\/blood.V58.3.420.420","article-title":"Chromosome studies in adult T\u2010cell leukemia in Japan: Significance of trisomy 7","volume":"58","author":"Ueshima Y.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170108"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910300304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910300304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:13:55Z","timestamp":1699802035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910300304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9,15]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,9,15]]}},"alternative-id":["10.1002\/ijc.2910300304"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910300304","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,9,15]]}}}