{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:34:21Z","timestamp":1699835661026},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":8616,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1982,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A newly synthetized rutin derivative, rutin\u2010<jats:italic>N<\/jats:italic>\u2010mustard, showed a marked antiproliferative effect on NK\/Ly ascites tumour cells <jats:italic>in vivo.<\/jats:italic> When administered i.p. or i.v., this compound increased the survival time of the animals, but oral administration had no such effect. The drug was not able to kill the tumour cells, since the chromium release from the rutin\u2010<jats:italic>N<\/jats:italic>\u2010mustard\u2010treated tumour cells was the same as in the case of the controls. Tumour growth was completely inhibited in the animals when the cells were pretreated with 100 mg\/kg rutin\u2010<jats:italic>N<\/jats:italic>\u2010mustard before transplantation. The results also showed that rutin\u2010<jats:italic>N<\/jats:italic>\u2010mustard has little effect on the xenogenization of NK\/Ly tumour cells. We presume that the antiproliferative action of rutin\u2010<jats:italic>N<\/jats:italic>\u2010mustard is due to its alkylating activity.<\/jats:p>","DOI":"10.1002\/ijc.2910300615","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:11:59Z","timestamp":1171912319000},"page":"767-771","source":"Crossref","is-referenced-by-count":1,"title":["The effect of rutin\u2010<i>N<\/i>\u2010mustard on the survival of NK\/Ly ascites tumour\u2010bearing mice"],"prefix":"10.1002","volume":"30","author":[{"given":"J.","family":"Moln\u00e1r","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Mucsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"M\u00e1ndi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"B\u00e9l\u00e1di","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"F\u00f6lde\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Boda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.327550"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0021-9258(18)65133-6","article-title":"The metabolic fate of rutin and quercetin in the animal body","volume":"223","author":"Both A. N.","year":"1956","journal-title":"J. biol. Chem."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(79)90083-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1950.82910510004009"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50001a002"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3988.1148"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1300141"},{"key":"e_1_2_1_9_1","first-page":"943","article-title":"Effects of 5\u2010(3,3\u2010dimethyl\u20101\u2010triazeno) imidazole\u20104\u2010carboxamide, 1\u2010(2\u2010chloroethyl)\u20103\u2010(4\u2010methylcyclohexyl)\u20101\u2010nitrosourea and L\u2010phenylalanine mustard on B16, Cloudman S91, and Harding\u2010Passey mouse melanomas","volume":"39","author":"Hill G. J.","year":"1979","journal-title":"Cancer Res."},{"key":"e_1_2_1_10_1","first-page":"14","article-title":"New drugs of 1977, I","volume":"150","author":"Hussar A. B.","year":"1977","journal-title":"Amer. J. Pharm."},{"key":"e_1_2_1_11_1","first-page":"116","volume-title":"Xenogenization of lymphocytes, erythroblasts and tumour cells","author":"Kobayashi J.","year":"1978"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(74)90002-4"},{"key":"e_1_2_1_13_1","first-page":"99","article-title":"A simplified method of evaluating dose\u2010effect experiment","volume":"96","author":"Litchfield J.","year":"1949","journal-title":"J. pharm. exp. Ther."},{"key":"e_1_2_1_14_1","first-page":"614","article-title":"Ion transport and protein synthesis in dextransulphate treated ascites tumours cells","volume":"34","author":"McCoy C. D.","year":"1975","journal-title":"Fed. Proc."},{"key":"e_1_2_1_15_1","first-page":"11","article-title":"Antitumour activity of flavonoids on NK\/Ly ascites tumour cells","volume":"28","author":"Moln\u00e1r J.","year":"1981","journal-title":"Neoplasma"},{"key":"e_1_2_1_16_1","first-page":"2197","article-title":"Regional differences in the growth of tumour cells injected intraperitoneally into syngeneic adult mice","volume":"40","author":"Morrissey L. W.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_17_1","first-page":"337","article-title":"A new mouse ascites tumour to be used as a screening tool","volume":"8","author":"N\u00e9meth L.","year":"1961","journal-title":"Neoplasma"},{"key":"e_1_2_1_18_1","first-page":"3172","article-title":"Studies of nitrogen mustard transport by mouse myeloma and hemopoietic precursor cells","volume":"33","author":"Ogawa M.","year":"1973","journal-title":"Cancer Res."},{"key":"e_1_2_1_19_1","volume-title":"Biological alkylating agents. Fundamental chemistry and the design of compounds for selective toxicity","author":"Ross W. C. J.","year":"1962"},{"key":"e_1_2_1_20_1","first-page":"1865","article-title":"The effect of flavonoids on aerobe glycolysis and growth of tumour cells","volume":"35","author":"Suolinna E. M.","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_1_21_1","first-page":"1038","article-title":"Increased immunosensitivity in nitrogen\u2010mustard\u2010resistant Yoshida sarcoma","volume":"33","author":"Tsukagoshi S.","year":"1973","journal-title":"Cancer Res."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197611)38:5<1887::AID-CNCR2820380504>3.0.CO;2-#"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910300615","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910300615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T16:15:01Z","timestamp":1699805701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910300615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12,15]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,12,15]]}},"alternative-id":["10.1002\/ijc.2910300615"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910300615","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,12,15]]}}}