{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:30:19Z","timestamp":1759332619213},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8525,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1983,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ability of the JHM<jats:sup>3<\/jats:sup> strain of mouse hepatitis virus (MHV) to induce natural killer (NK) cells was examined. Infection of C57BU6 (86) mice with this virus resulted in the augmentation of natural cytotoxicity against YAC\u2010I target cells in the absence of a detectable interferon response. The cells responsible for this increased cytotoxicity were sensitive to complement\u2010mediated lysis with an anti\u2010Q\u20105 reagent but not with a Thy 1.2 antiserum, indicating that they possess an NK\u2010like surface phenotype. Although variation in the NK response of individual B6 mice following JHM virus infection was found, even the animal with the most responsive NK cell population had no detectable interferon in the spleen. This finding contrasted with observations with an unrelated virus (lymphocytic choriomeningitis virus) and a serologically related strain of MHV. Infection with both of these viruses induced augmented NK cell activity and interferon responses. In addition, we found that neither the ability to mount an augmented NK cell response nor preferential lysis of virus\u2010infected targets correlated with resistance or susceptibility to JHM virus infection.<\/jats:p>","DOI":"10.1002\/ijc.2910310310","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:08:34Z","timestamp":1171912114000},"page":"309-314","source":"Crossref","is-referenced-by-count":22,"title":["Natural killer cell activity during mouse hepatitis virus infection: Response in the absence of interferon"],"prefix":"10.1002","volume":"31","author":[{"given":"Stephen A.","family":"Stohlman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Brayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Harmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland G.","family":"Ganges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn K.","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(81)80007-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"988","DOI":"10.4049\/jimmunol.126.3.988","article-title":"Genetic influences on the augmentation of natural killer (NK) cells during murine\u2010cytomegalovirus infection: correlation with patterns of resistance","volume":"126","author":"Bancroft G.","year":"1981","journal-title":"J. Immunol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830061209"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(76)90029-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290313"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.4049\/jimmunol.124.5.2137","article-title":"Therapy of leukemia by nonimmune syngeneic spleen cells","volume":"124","author":"Cheever M. A.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.4049\/jimmunol.127.6.2391","article-title":"Immune responsiveness of SM\/J mice: hyper NK cell activity by NK1+ Qa 5\u2212 cells","volume":"127","author":"Clark E. A.","year":"1981","journal-title":"J. Immunol."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60659-4"},{"key":"e_1_2_1_10_1","first-page":"218","article-title":"Biological behavior of malignant melanoma cells correlated to their survival in vivo","volume":"35","author":"Fidler I.","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/273759a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.4049\/jimmunol.125.5.2225","article-title":"Effect of interferon and interferon inducers on the NK sensitivity of normal mouse thymocytes","volume":"125","author":"Hansson M.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60936-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910160204"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190417"},{"key":"e_1_2_1_16_1","first-page":"873","volume-title":"Natural cell\u2010mediated immunity against tumors","author":"Herberman R. B.","year":"1980"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.149.5.1260"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290513"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910210410"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830050208"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1979.tb00270.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4049\/jimmunol.125.3.1003","article-title":"Antigenic profile of murine natural killer cells","volume":"125","author":"Koo G. C.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.4049\/jimmunol.118.3.928","article-title":"Characterization of the blastogenic and cytotoxic responses of normal mice to ecotropic C type viral gp 71","volume":"18","author":"Lee J. C.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/297415a0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910280621"},{"key":"e_1_2_1_26_1","first-page":"2067","article-title":"The mononuclear cell in human blood which mediates ADCC to virus infected targets. I. Identification of the population of effector cells","volume":"117","author":"Rodda S.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.3.1405"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(82)90138-6"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4049\/jimmunol.121.2.532","article-title":"Cell\u2010mediated cytotoxicity against virus\u2010infected target cells in humans. II. Interferon induction and activation of natural killer cells","volume":"121","author":"Santoli D.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_30_1","first-page":"869","article-title":"Activation of natural killer cells and induction of interferon after injection of mouse hepatitis virus type 3 in mice. Infect","volume":"35","author":"Schindler L.","year":"1982","journal-title":"Immun."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01563919"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.4049\/jimmunol.124.4.1733","article-title":"Resistance to fatal central nervous system disease by mouse hepatitis virus, strain JHM. II. Adherent cell mediated protection","volume":"124","author":"Stohlman S. A.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01315637"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.1.38"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01315640"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68069-4_6"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.4049\/jimmunol.124.5.2491","article-title":"Effect of virus infections on target cell susceptibility to natural killer cell\u2010mediated lysis","volume":"124","author":"Welsh R. M.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_38_1","first-page":"1127","article-title":"Neuro\u2010pathological effects of persistent infection of the mouse hepatitis virus (MHV\u20103). Infection","volume":"12","author":"Virelizier J. L.","year":"1975","journal-title":"Immun."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910310310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910310310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T23:56:19Z","timestamp":1697759779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910310310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3,15]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,3,15]]}},"alternative-id":["10.1002\/ijc.2910310310"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910310310","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,3,15]]}}}