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Co\u2010cultivation of normal unbilical cord blood with lethally irradiated, HTLV\u2010positive lymphocytes established in culture from many of these patients resulted in the productive infection of the cord blood T\u2010lymphocytes which grew in suspension culture in the absence of exogenous TCGF. These transformed cord blood cells have morphological and cytochemical properties similar to HTLV\u2010positive fresh and cultured tumor T\u2010cells and are distinguishable from virus donor cells by HLA haplotype and chromosomal markers. These cells express HTLV proteins, release type\u2010C virus particles and contain surface receptors for TCGF. These results demonstrate that HTLV isolated from T\u2010cell leukemic donors from different parts of the world can productively infect and transform fresh human cord blood T\u2010lymphocytes, and that the transformed cells share many similarities with fresh or cultured leukemic cells.<\/jats:p>","DOI":"10.1002\/ijc.2910310404","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:07:32Z","timestamp":1171912052000},"page":"413-420","source":"Crossref","is-referenced-by-count":76,"title":["Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T\u2010cell leukemia\u2010lymphoma virus (HTLV)"],"prefix":"10.1002","volume":"31","author":[{"given":"Phillip D.","family":"Markham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Z.","family":"Salahuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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