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EBV conversion of the EBV\u2010negative Burkitt lymphoma line Ramos destabilized the high BLA expression, leading to a decrease in the average number of positive cells in the majority of the converted sublines in parallel with considerable fluctuation in antigen expression within each subline. Our group has previously shown that EBV\u2010conversion of Ramos cells can induce certain differentiation steps (Spira <jats:italic>et al.<\/jats:italic>, 1981 <jats:italic>a<\/jats:italic>). EBV\u2010converted sublines of another EBV\u2010negative Burkitt lymphoma, BJAB, showed a much greater stability previously and remained unchanged with regard to BLA expression in our present experiments. Eight T\u2010cell leukemias, three myeloid leukemia lines and two diffuse histiocytic lymphomas were negative for BLA, whereas two myeloma lines were 30\u201040% positive. A histiocytic tumor had marginal reactions. Hybrids derived from the fusion of high with low BLA\u2010reactive parental lines showed all three possible patterns (high, intermediate and low), provided that B\u2010cell lines were fused with each other. Fusion of two Burkitt lymphoma lines with the K562 erythroleukemia line led to the extinction of BLA expression, as well as to the eclipse of other B\u2010cell markers. B\u2010lymphoma and leukemia (CLL) cells harvested directly from the patient showed a heterogeneous reactivity pattern. Strong to intermediate BLA expression was found among CLL cells and in most histological groups of B\u2010CLL lymphomas except the centroblastic group (3\/3 negatives). IgG\u2010expressing follicular lymphomas were less reactive than IgM \u00b1 IgD lymphomas of the same group. Immunocytomas were also low\u2010reactive. BLA can be thus expressed on a variety of B\u2010cell neoplasms; the degree of its expression appears to be related to the stage of differentiation.<\/jats:p>","DOI":"10.1002\/ijc.2910310503","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:35:51Z","timestamp":1171913751000},"page":"535-542","source":"Crossref","is-referenced-by-count":35,"title":["Expression of the bla antigen, defined by the monoclonal 38.13 antibody, on burkitt lymphoma lines, lymphoblastoid cell lines, their hybrids and other b\u2010cell lymphomas and leukemias"],"prefix":"10.1002","volume":"31","author":[{"given":"George","family":"Klein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Manneborg\u2010Sandlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbro","family":"Ehlin\u2010Henriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tore","family":"Godal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Wiels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tursz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1121","article-title":"Direct implantation and serial transplantation of human lymphoblastic leukemia in hamsters, S. 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