{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:23:31Z","timestamp":1698362611030},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":8434,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1983,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Administration of ethylnitrosourea (ENU) to pregnant rats in the late stage of gestation has been known to have a mainly neurocarcinogenic action on the progeny. However, when transplacental administration of ENU was combined in postnatal life with a brief dietary exposure to 2\u2010acetylaminofluorene (2\u2010AAF) and a two\u2010thirds partial hepatectomy, numerous focal hyperplastic lesions of \u03b3\u2010glutamyltranspeptidase (GGT)\u2010positive hepatocytes emerged in the liver of the progeny. On the other hand, rats of F<jats:sub>2<\/jats:sub> generation born of F<jats:sub>1<\/jats:sub> parents and F<jats:sub>3<\/jats:sub> rats born of F<jats:sub>2<\/jats:sub> parents showed no increase in the incidence of hepatic lesions after treatment with the same dietary regimen. It was suggested that direct interaction between fetal liver cells and the carcinogen is important for occurrence of initiated hepatocytes and that the initiation effect on rat liver by ENU does not persist in the descendants of F<jats:sub>2<\/jats:sub> and F<jats:sub>3<\/jats:sub> generations.<\/jats:p>","DOI":"10.1002\/ijc.2910310617","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:35:12Z","timestamp":1171913712000},"page":"775-777","source":"Crossref","is-referenced-by-count":3,"title":["Initiation of focal hyperplastic hepatic lesions by transplacental administration of ethylnitrosourea in rats of F<sub>1<\/sub> generation, and no transmission of the effect to F<sub>2<\/sub> and F<sub>3<\/sub> generations"],"prefix":"10.1002","volume":"31","author":[{"given":"Katsuhiro","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinya","family":"Yokokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tomoyori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Narasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200218"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-135-34993"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00524174"},{"key":"e_1_2_1_5_1","first-page":"58","article-title":"The incidence of tumors among offspring of mice exposed to orthoaminoazotoluene","volume":"7","author":"Gelstein V. 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