{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:20:15Z","timestamp":1755696015514},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8341,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1983,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum and peripheral blood cell samples from eleven relatives of a T\u2010cell leukemia patient with human T\u2010cell leukemia\/lymphoma virus (HTLV)\u2010associated disease, were investigated for the presence of HTLV antibody and antigen expression. In addition to the patient, three family members were seropositive and a wide range in HTLV antibody titer was observed. The father of the patient showed the highest titer (173,000) and carried HTLV p19+ cells in his peripheral blood. Upon induction of proliferation of these cells by short\u2010term culture in the presence of phytohemagglutinin (PHA) and 12\u2010<jats:italic>O<\/jats:italic>\u2010tetradecanoyl phorbol\u201013\u2010acetate (TPA), an increase from 1% to 28% HTLV p19+ cells was observed confirming previous findings that HTLV p19 expression was correlated with proliferative activity of the host cells. In none of the other seronegative or seropositive relatives of the patient HTLV p19 expression was revealed when tested in freshly isolated mononuclear cells, upon short\u2010term incubation in PHA + TPA or after prolonged culture for 2 or 3 passages in medium containing T\u2010cell growth factor. The results from HLA typing studies did not provide any evidence for HTLV related abnormalities in haplotype expression. Our data confirmed the earlier notion of a prevalence of HTLV infection within families of patients with HTLV\u2010associated disease. It is furthermore obvious from our results that a normal individual may possess high titer HTLV antibody and circulating HTLV p19+ cells without showing signs of disease.<\/jats:p>","DOI":"10.1002\/ijc.2910320313","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:31:20Z","timestamp":1171913480000},"page":"337-342","source":"Crossref","is-referenced-by-count":23,"title":["Antibodies against human T\u2010cell leukemia\/lymphoma virus (HTLV) and expression of HTLV p19 antigen in relatives of a T\u2010cell leukemia patient originating from Surinam"],"prefix":"10.1002","volume":"32","author":[{"given":"Florry A.","family":"Vyth\u2010Dreese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"R\u00fcmke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Robert\u2010Guroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerda","family":"De Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90056-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300302"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","unstructured":"Blayney D. W. Jaffe E. S. Blattner W. A. Cossman J. Robert\u2010Guroff M. Longo D. L. Bunn P. A. andGallo R. C. The human T\u2010cell leukemia\/lymphoma virus (HTLV) associated with American adult T\u2010cell leukemia\/lymphoma (ATL).Blood in press (1983).","DOI":"10.1182\/blood.V62.2.401.bloodjournal622401"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Bunn P. A. Jr. Schechter G. P. Jaffe E. Blayney D. Young R. C. Matthews M. J. Blattner W. Broder S. Robert\u2010Guroff M. andGallo R. C. Clinical course of retrovirus\u2010associated adult T\u2010cell lymphoma in the United States.New Engl. J. 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Phenotypic and functional characterization of HTLV positive neoplastic T cells cultured with interleukin\u20102. I. Retention of morphology phenotype and selective cytotoxic properties in longterm culture.Leukemia Res. in press (1983b).","DOI":"10.1016\/0145-2126(84)90027-4"},{"key":"e_1_2_1_44_1","doi-asserted-by":"crossref","unstructured":"Vyth\u2010Dreese F. A. andde Vries J. E. Phenotypic and functional characterization of HTLV positive neoplastic T cells cultured with interleukin\u20102. II. Inhibition of lymphoproliferative responses by cultured neoplastic T cells.Leukemia Res. in press (1983c).","DOI":"10.1016\/0145-2126(84)90028-6"},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1182\/blood.V60.6.1437.1437","article-title":"Phorbol ester\u2010mediated induction and augmentation of mitogenesis and interleukin\u20102 production in human T\u2010cell lymphoproliferative disease","volume":"60","author":"Vyth\u2010Dreese F. 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