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Additionally, cell cycle analysis on cell suspensions was performed by DNA flow cytofluorometry. In 33 (87%) lymphomas the malignant cells expressed monoclonal surface immunoglobulin (Ig), which indicated B\u2010cell origin of tumors. In 7 of the 19 B\u2010cell lymphomas tested by the peroxidase\u2010antiperoxidase method, cytoplasmic Ig was found. Four lymphomas were of T\u2010cell and one of non\u2010B\/non\u2010T\u2010cell origin. In 11 B\u2010cell and 2 lymphoblastic non\u2010B\u2010cell tumors, common acute lymphobiastk leukemia antigen (CALLA) was found. In 25 of 30 studied NHL the mafignant cells expressed receptor for transferrin and in 19 of 28 cases a high percentage of cells in S\u2010phase (&gt; 10.85%) was found. Number and distribution as well as type of non\u2010B\u2010cell infiltrating B\u2010cell\u2010derived lymphomas varied considerably from case to case. Among these cells Leu 3<jats:sup>+<\/jats:sup> (T heloer\/inducer) cells predominated. Leu 2<jats:sup>+<\/jats:sup> (T suppressor\/cytotoxk) and Leu 7<jats:sup>+<\/jats:sup> (natural killer and killer) cells constituted less numerous groups. Correlation of cytodiagnostic analyses with clinical observations indicates that high content of infiltrating T cells may be a favorable prognostic feature in highly malignant B\u2010cell lymphomas.<\/jats:p>","DOI":"10.1002\/ijc.2910320604","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:27:03Z","timestamp":1171913223000},"page":"667-674","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of malignant and non\u2010neoplastic cell phenotypes in highly malignant non\u2010Hodgkin lymphomas"],"prefix":"10.1002","volume":"32","author":[{"given":"Anna","family":"Porwit\u2010Ksiazek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Christensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Lindemalm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Mellstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Tribukait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnel","family":"Biberfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Biberfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1182\/blood.V61.3.469.469","article-title":"Monoclonal antibody studies in non\u2010Hodgkin's lymphoma","volume":"61","author":"Aisenberg A. 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